WebMD Medication Abortion. However this procedure is not yet FDA approved. ACAAI Member Login. 7. UpToDate Cytotec Abortion pill is the common name for using two different medicines to end a pregnancy: mifepristone and misoprostol. Please know, this use of progesterone for the reversal of mifepristone is not yet FDA approved. Surgical abortion Fertility and Sterility is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. Vacuum aspiration takes about 5 to 10 minutes and most women go home a few hours later. Selected Practice Recommendations for Contraceptive What happens You can self-refer by contacting an abortion provider directly. (see Contraindications). Home Page: Gastroenterology If you cannot find the number, contact a GP or 111. Align your practice with the latest evidence-based recommendations for treatment sequencing and combination approaches in advanced melanoma. Bernard, N., Elefant, E., Carlier, P., Tebacher, M., Barjhoux, CE., Bos-Thompson, MA., Amar, E., Descotes, J., Vial, T. (2013). Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications. Currently, misoprostol is FDA approved only for the prevention and treatment of NSAID-induced gastric ulcers in patients taking NSAIDs and at high risk for ulceration. This usually happens at the hospital or clinic, but you may be offered a phone or video assessment. Success rates from APR are from small studies and are very similar to those who only take mifepristone without any progesterone treatment. Radiotherapy for Breast Cancer in Combination With Novel Systemic Therapies Editor-in-Chief Dr. Sue Yom hosts Dr. Sara Alcorn, Associate Editor and Associate Professor of Radiation Oncology at the University of Minnesota, who first-authored this months Oncology Scan, Toxicity and Timing of Breast Radiotherapy with Overlapping Systemic Therapies and Dr. Effectiveness should be verified two weeks after use. Misoprostol might be helpful in select circumstances (e.g., in women with a recent failed insertion). While doctors can do vacuum aspirations until about 14 weeks, the most common type of second-trimester abortion is called dilation and evacuation, or D&E. Surgical abortion After 15 minutes, a second bolus dose of 0.35 mg/kg IV (20 to 25 mg is a typical dose) over 2 minutes may be administered, if needed. A tube is inserted into the womb through the cervix (the opening to the womb from the vagina), and the pregnancy is removed using suction. The American Association of Pro-Life Obstetricians and Gynecologists (AAPLOG) believes that the procedure is safe and significantly more effective than seeing what happens without the second medication, misoprostol. Progesterone, used in the reversal process, has been safely used in pregnancy for more than 50 years. Editor/authors are masked to the peer review process and editorial decision-making of their own work and are not able to access this work in the online manuscript submission system. The maximum concentration of misoprostol acid in expressed breast milk was achieved within 1 hour after dosing and was 7.6 pg/ml (CV 37%) and 20.9 pg/ml (CV 62%) after single 200 g and 600 g misoprostol administration, respectively. Misoprostol is not recommended for routine use before IUD insertion. is taken orally and is ineffective after the second set of pills (misoprostol). It is not possible to know exactly when the cramping and bleeding will start, most often it is within the first 24 hours of the first dose of Misoprostol, but it could be several hours later. Misoprostol Cytotec MSN Surgical abortion involves an operation to remove the pregnancy from the womb. Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. Selected Practice Recommendations for Contraceptive Seventy-six percent of women successfully aborted within 12 hours after insertion of misoprostol. BJOG, 120(5), 568-575. You will not know if pills sold online are genuine and they could be harmful. Mifepristone-induced cervical ripening: Structural, biomechanical, and molecular events. The abortion pill reversal (APR) procedure can only occur after the first dose of medical abortion (mifepristone/RU-486) is taken orally and is ineffective after the second set of pills (misoprostol). warning. Dont smoke, and limit alcohol. Editor/authors are masked to the peer review process and editorial decision-making of their own work and are not able to access this work 3. It's against the law to try to cause your own abortion. (ACOG itself has research confirming this). Most people having an abortion do not usually need to stay in the clinic or hospital overnight, but you may need to go to appointments on different days. After a single oral dose of misoprostol to nursing mothers, misoprostol acid was excreted in breast milk. Before doing anything, contact an abortion advice service such as the British Pregnancy Advisory Service (BPAS), MSI Reproductive Choices UK, a GP or sexual health service, who can help you find appropriate care for free and in confidence. Thus, since this is a medical procedure, it would follow that abortion education would include the option for apossiblereversal, whether that means simply not taking the second set of pills and continuing prenatal care, or finding a physician that will perform the reversal procedure with progesterone. You may be able to have a medical abortion at home, without going to a hospital or clinic, if you're less than 10 weeks pregnant. How does a medication abortion feel? In clinical trials, over 15,000 patients and subjects received at least one dose of misoprostol. Because of that, doctors often recommend taking a second dose of misoprostol, which can boost its effectiveness back up to 98%. Chabbert-Buffet, N., Meduri, G., Bouchard, P., & Spitz, I. M. (2005). When you're sure you want to have an abortion, you'll be asked to sign a consent form and the clinic or hospital will arrange a date for the abortion. The Abortion Pill This happens either a few hours or 1 to 2 days before the operation, depending on the medicine used. Yes, the American Association of Pro-Life Obstetricians and Gynecologists (AAPLOG) supports the procedure and in its public statement on abortion pill reversal, states three important things: There are a few organizations that do not support the use of the reversal procedure, such as NARAL Pro-Choice America, Planned Parenthood, and ACOG (American Congress of Obstetricians and Gynecologists). (It is true that more studies may be needed, but there is a small population that can even be studied, making it a challenge. This is equivalent to 60% of the recommended dose for thrush in newborns younger than 2 weeks of age and 20% of the recommended dose for older newborns and infants. It normally takes about 10 to 20 minutes and you're usually able to go home the same day. https://doi.org/10.1016/J.AJOG.2005.11.026, 5. ASRM Fact Sheet: Progesterone supplementation during the luteal phase and in early pregnancy in the treatment of infertility: an educational bulletin. Reach out to a healthcare professional or seek emergency care if you: Most people ending a pregnancy in the second or third trimester undergo a surgical abortion. It also aims to reduce variation in areas of care such as fetal monitoring during The abortion pill reversal (APR) procedure can only occur after the first dose of medical abortion (mifepristone/RU-486) is taken orally and is ineffective after the second set of pills (misoprostol). The success rate was increased to 84% after a second dose of 800 micrograms of vaginal misoprostol was administered if needed. within 4 to 6 hours of taking the second medicine, the lining of the womb breaks down, causing pain, bleeding and loss of the pregnancy; Sometimes you need to take more doses of misoprostol to get the pregnancy to pass. Misoprostol D&E is usually carried out under sedation or general anaesthetic. ACAAI Member, full access to the journal is a member benefit. Diflucan (fluconazole) dose, indications, adverse effects Early Pregnancy Loss Misoprostol has four primary effects: cytoprotection of the gastrointestinal mucosa, uterotonic, diarrhea, and abdominal pain (diarrhea and abdominal pain are considered adverse effects). Their main concerns are: It is important to note that when any medical procedure is performed, the physician informs the patient of whether the process is permanent or may be reversed. The protocol is only effective within 24 hours of taking mifepristone and involves a large influx of progesterone into the pregnant womans system. American Pregnancy Association If you have a general anaesthetic, you'll be fully asleep during the operation and will not remember anything. The pregnancy is passed (comes out) through the vagina. Medical and surgical abortions can generally only be carried out up to 24 weeks of pregnancy. You may experience a range of emotions after an abortion. Continuation of pregnancy after first-trimester exposure to mifepristone: an observational prospective study. The American College of Obstetricians and Gynecologists, Practice Bulletin number 143, March 2014. AJOG's Editors have active research programs and, on occasion, publish work in the Journal. Ninety-six percent of women had a successful medical abortion after the first or second dose of misoprostol. Home Page: American Journal of Obstetrics & Gynecology Medical Abortion Misoprostol is a synthetic prostaglandin medication used to prevent and treat stomach and duodenal ulcers, induce labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. They will be able to provide counselling or refer you for counselling if you need it. Some patients may respond to an initial bolus dose of 0.15 mg/kg; however, experience with this dose is limited and the duration of action may be shorter. Diclofenac; Misoprostol: (Major) In certain cases, oxytocin can be used in combination with other oxytocics for therapeutic purposes. Merck Manuals Consumer Version WebMD Nausea, vomiting, diarrhea, weakness, or dizziness may occur. PRIME Continuing Medical Education This combination is 97% effective during the first 63 days of pregnancy. ), That offering the reversal procedure undermines a womans ability to choose, perhaps by implying that women must not have thought it through, and so need an option to get out. 6. How does the abortion pill work? Occasionally, the pregnancy does not pass and an operation is needed to remove it. Others show that it is more effective and is indeed safe to use progesterone after mifepristone. It is also effective in the second trimester of pregnancy. Term Abortion Abortions can only be carried out under the care of hospitals or licensed clinics, by qualified doctors. The guideline helps women to make an informed choice about where to have their baby. Because of that, doctors often recommend taking a second dose of misoprostol, which can boost its effectiveness back up to 98%. Before a surgical abortion, you'll be asked to have a medicine to open the cervix. Is there enough research or backing to say what works and is safe? For abortions it is used by itself and with mifepristone or methotrexate. Hysterectomy is the second most frequently performed surgical procedure (after cesarean section) for U.S. women who are of reproductive age. Bleeding usually lasts a week or two. cytotec (misoprostol) administration to women who are pregnant can cause birth defects, abortion, premature birth or uterine rupture.. uterine rupture has been reported when cytotec was administered in pregnant women to induce labor or to induce abortion. Home Page: Contraception If you need to discuss how you're feeling, contact the abortion service or your GP. For those infants who survive mifepristone, there is no evidence of birth defects associated with the medication. Human Conception: The Beginning of Life There is much confusion and disagreement today about when human life actually begins. Lets talk about your pregnancy Its, Establishing Paternity with Paternity Tests, Can I get pregnant ifand other questions about conception, Products & Tests to Support Your Pregnancy, Supplements and Medications for a Healthy Pregnancy, https://aaplog.org/wp-content/uploads/2017/02/AAPLOG-APR-Fact-Sheet.pdf, Progesterone has been safely used during pregnancy for decades without undesired effects. Occasionally, the pregnancy does not pass and an operation is needed to remove it. You can also take the drug misoprostol to boost the amount of protective mucus your stomach makes. A more recent group of NSAIDs known as COX-2 selective or COX-2 specific inhibitors are covered in a separate article on COX-2 inhibitors presently limited to the agent celecoxib (Celebrex.). Mifepristone works by blocking the hormone progesterone. Now Free Online - The Consumer Version of the Merck Manuals (known as the MSD Manuals outside of US & Canada) is the standard in home medical reference - since 1899. within 4 to 6 hours of taking the second medicine, the lining of the womb breaks down, causing pain, bleeding and loss of the pregnancy; Sometimes you need to take more doses of misoprostol to get the pregnancy to pass. The clinic will give you the number of a 24-hour helpline to call if you're worried. very heavy bleeding with large clots (If you dont have any bleeding within 24 hours after taking the second medicine, misoprostol, call your nurse or doctor.) This can be used up to 14 weeks of pregnancy. In this second video activity of the melanoma resource center, expert melanoma faculty will discuss the latest clinical safety and efficacy data for combination therapy and sequencing approaches, For most people, medication abortion feels like having an early miscarriage. See also Warning section. Some say that treatment with progesterone after the first pill (mifepristone) is no more effective than just letting nature take its course, and that excess progesterone can be unsafe. But that can cause side effects like diarrhea and stomach cramps. Many women are treated for conditions that do not necessarily require treatment, and the side effects of these treatments can cause more health problems than the actual condition. Contraceptions Editors have active research programs and, on occasion, publish work in Contraception. Does This is used after 14 weeks of pregnancy. 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https://aaplog.org/wp-content/uploads/2017/02/AAPLOG-APR-Fact-Sheet.pdf. WebMD Medication Abortion. However this procedure is not yet FDA approved. ACAAI Member Login. 7. UpToDate Cytotec Abortion pill is the common name for using two different medicines to end a pregnancy: mifepristone and misoprostol. Please know, this use of progesterone for the reversal of mifepristone is not yet FDA approved. Surgical abortion Fertility and Sterility is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. Vacuum aspiration takes about 5 to 10 minutes and most women go home a few hours later. Selected Practice Recommendations for Contraceptive What happens You can self-refer by contacting an abortion provider directly. (see Contraindications). Home Page: Gastroenterology If you cannot find the number, contact a GP or 111. Align your practice with the latest evidence-based recommendations for treatment sequencing and combination approaches in advanced melanoma. Bernard, N., Elefant, E., Carlier, P., Tebacher, M., Barjhoux, CE., Bos-Thompson, MA., Amar, E., Descotes, J., Vial, T. (2013). Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications. Currently, misoprostol is FDA approved only for the prevention and treatment of NSAID-induced gastric ulcers in patients taking NSAIDs and at high risk for ulceration. This usually happens at the hospital or clinic, but you may be offered a phone or video assessment. Success rates from APR are from small studies and are very similar to those who only take mifepristone without any progesterone treatment. Radiotherapy for Breast Cancer in Combination With Novel Systemic Therapies Editor-in-Chief Dr. Sue Yom hosts Dr. Sara Alcorn, Associate Editor and Associate Professor of Radiation Oncology at the University of Minnesota, who first-authored this months Oncology Scan, Toxicity and Timing of Breast Radiotherapy with Overlapping Systemic Therapies and Dr. Effectiveness should be verified two weeks after use. Misoprostol might be helpful in select circumstances (e.g., in women with a recent failed insertion). While doctors can do vacuum aspirations until about 14 weeks, the most common type of second-trimester abortion is called dilation and evacuation, or D&E. Surgical abortion After 15 minutes, a second bolus dose of 0.35 mg/kg IV (20 to 25 mg is a typical dose) over 2 minutes may be administered, if needed. A tube is inserted into the womb through the cervix (the opening to the womb from the vagina), and the pregnancy is removed using suction. The American Association of Pro-Life Obstetricians and Gynecologists (AAPLOG) believes that the procedure is safe and significantly more effective than seeing what happens without the second medication, misoprostol. Progesterone, used in the reversal process, has been safely used in pregnancy for more than 50 years. Editor/authors are masked to the peer review process and editorial decision-making of their own work and are not able to access this work in the online manuscript submission system. The maximum concentration of misoprostol acid in expressed breast milk was achieved within 1 hour after dosing and was 7.6 pg/ml (CV 37%) and 20.9 pg/ml (CV 62%) after single 200 g and 600 g misoprostol administration, respectively. Misoprostol is not recommended for routine use before IUD insertion. is taken orally and is ineffective after the second set of pills (misoprostol). It is not possible to know exactly when the cramping and bleeding will start, most often it is within the first 24 hours of the first dose of Misoprostol, but it could be several hours later. Misoprostol Cytotec MSN Surgical abortion involves an operation to remove the pregnancy from the womb. Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. Selected Practice Recommendations for Contraceptive Seventy-six percent of women successfully aborted within 12 hours after insertion of misoprostol. BJOG, 120(5), 568-575. You will not know if pills sold online are genuine and they could be harmful. Mifepristone-induced cervical ripening: Structural, biomechanical, and molecular events. The abortion pill reversal (APR) procedure can only occur after the first dose of medical abortion (mifepristone/RU-486) is taken orally and is ineffective after the second set of pills (misoprostol). warning. Dont smoke, and limit alcohol. Editor/authors are masked to the peer review process and editorial decision-making of their own work and are not able to access this work 3. It's against the law to try to cause your own abortion. (ACOG itself has research confirming this). Most people having an abortion do not usually need to stay in the clinic or hospital overnight, but you may need to go to appointments on different days. After a single oral dose of misoprostol to nursing mothers, misoprostol acid was excreted in breast milk. Before doing anything, contact an abortion advice service such as the British Pregnancy Advisory Service (BPAS), MSI Reproductive Choices UK, a GP or sexual health service, who can help you find appropriate care for free and in confidence. Thus, since this is a medical procedure, it would follow that abortion education would include the option for apossiblereversal, whether that means simply not taking the second set of pills and continuing prenatal care, or finding a physician that will perform the reversal procedure with progesterone. You may be able to have a medical abortion at home, without going to a hospital or clinic, if you're less than 10 weeks pregnant. How does a medication abortion feel? In clinical trials, over 15,000 patients and subjects received at least one dose of misoprostol. Because of that, doctors often recommend taking a second dose of misoprostol, which can boost its effectiveness back up to 98%. Chabbert-Buffet, N., Meduri, G., Bouchard, P., & Spitz, I. M. (2005). When you're sure you want to have an abortion, you'll be asked to sign a consent form and the clinic or hospital will arrange a date for the abortion. The Abortion Pill This happens either a few hours or 1 to 2 days before the operation, depending on the medicine used. Yes, the American Association of Pro-Life Obstetricians and Gynecologists (AAPLOG) supports the procedure and in its public statement on abortion pill reversal, states three important things: There are a few organizations that do not support the use of the reversal procedure, such as NARAL Pro-Choice America, Planned Parenthood, and ACOG (American Congress of Obstetricians and Gynecologists). (It is true that more studies may be needed, but there is a small population that can even be studied, making it a challenge. This is equivalent to 60% of the recommended dose for thrush in newborns younger than 2 weeks of age and 20% of the recommended dose for older newborns and infants. It normally takes about 10 to 20 minutes and you're usually able to go home the same day. https://doi.org/10.1016/J.AJOG.2005.11.026, 5. ASRM Fact Sheet: Progesterone supplementation during the luteal phase and in early pregnancy in the treatment of infertility: an educational bulletin. Reach out to a healthcare professional or seek emergency care if you: Most people ending a pregnancy in the second or third trimester undergo a surgical abortion. It also aims to reduce variation in areas of care such as fetal monitoring during The abortion pill reversal (APR) procedure can only occur after the first dose of medical abortion (mifepristone/RU-486) is taken orally and is ineffective after the second set of pills (misoprostol). The success rate was increased to 84% after a second dose of 800 micrograms of vaginal misoprostol was administered if needed. within 4 to 6 hours of taking the second medicine, the lining of the womb breaks down, causing pain, bleeding and loss of the pregnancy; Sometimes you need to take more doses of misoprostol to get the pregnancy to pass. Misoprostol D&E is usually carried out under sedation or general anaesthetic. ACAAI Member, full access to the journal is a member benefit. Diflucan (fluconazole) dose, indications, adverse effects Early Pregnancy Loss Misoprostol has four primary effects: cytoprotection of the gastrointestinal mucosa, uterotonic, diarrhea, and abdominal pain (diarrhea and abdominal pain are considered adverse effects). Their main concerns are: It is important to note that when any medical procedure is performed, the physician informs the patient of whether the process is permanent or may be reversed. The protocol is only effective within 24 hours of taking mifepristone and involves a large influx of progesterone into the pregnant womans system. American Pregnancy Association If you have a general anaesthetic, you'll be fully asleep during the operation and will not remember anything. The pregnancy is passed (comes out) through the vagina. Medical and surgical abortions can generally only be carried out up to 24 weeks of pregnancy. You may experience a range of emotions after an abortion. Continuation of pregnancy after first-trimester exposure to mifepristone: an observational prospective study. The American College of Obstetricians and Gynecologists, Practice Bulletin number 143, March 2014. AJOG's Editors have active research programs and, on occasion, publish work in the Journal. Ninety-six percent of women had a successful medical abortion after the first or second dose of misoprostol. Home Page: American Journal of Obstetrics & Gynecology Medical Abortion Misoprostol is a synthetic prostaglandin medication used to prevent and treat stomach and duodenal ulcers, induce labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. They will be able to provide counselling or refer you for counselling if you need it. Some patients may respond to an initial bolus dose of 0.15 mg/kg; however, experience with this dose is limited and the duration of action may be shorter. Diclofenac; Misoprostol: (Major) In certain cases, oxytocin can be used in combination with other oxytocics for therapeutic purposes. Merck Manuals Consumer Version WebMD Nausea, vomiting, diarrhea, weakness, or dizziness may occur. PRIME Continuing Medical Education This combination is 97% effective during the first 63 days of pregnancy. ), That offering the reversal procedure undermines a womans ability to choose, perhaps by implying that women must not have thought it through, and so need an option to get out. 6. How does the abortion pill work? Occasionally, the pregnancy does not pass and an operation is needed to remove it. Others show that it is more effective and is indeed safe to use progesterone after mifepristone. It is also effective in the second trimester of pregnancy. Term Abortion Abortions can only be carried out under the care of hospitals or licensed clinics, by qualified doctors. The guideline helps women to make an informed choice about where to have their baby. Because of that, doctors often recommend taking a second dose of misoprostol, which can boost its effectiveness back up to 98%. Before a surgical abortion, you'll be asked to have a medicine to open the cervix. Is there enough research or backing to say what works and is safe? For abortions it is used by itself and with mifepristone or methotrexate. Hysterectomy is the second most frequently performed surgical procedure (after cesarean section) for U.S. women who are of reproductive age. Bleeding usually lasts a week or two. cytotec (misoprostol) administration to women who are pregnant can cause birth defects, abortion, premature birth or uterine rupture.. uterine rupture has been reported when cytotec was administered in pregnant women to induce labor or to induce abortion. Home Page: Contraception If you need to discuss how you're feeling, contact the abortion service or your GP. For those infants who survive mifepristone, there is no evidence of birth defects associated with the medication. Human Conception: The Beginning of Life There is much confusion and disagreement today about when human life actually begins. Lets talk about your pregnancy Its, Establishing Paternity with Paternity Tests, Can I get pregnant ifand other questions about conception, Products & Tests to Support Your Pregnancy, Supplements and Medications for a Healthy Pregnancy, https://aaplog.org/wp-content/uploads/2017/02/AAPLOG-APR-Fact-Sheet.pdf, Progesterone has been safely used during pregnancy for decades without undesired effects. Occasionally, the pregnancy does not pass and an operation is needed to remove it. You can also take the drug misoprostol to boost the amount of protective mucus your stomach makes. A more recent group of NSAIDs known as COX-2 selective or COX-2 specific inhibitors are covered in a separate article on COX-2 inhibitors presently limited to the agent celecoxib (Celebrex.). Mifepristone works by blocking the hormone progesterone. Now Free Online - The Consumer Version of the Merck Manuals (known as the MSD Manuals outside of US & Canada) is the standard in home medical reference - since 1899. within 4 to 6 hours of taking the second medicine, the lining of the womb breaks down, causing pain, bleeding and loss of the pregnancy; Sometimes you need to take more doses of misoprostol to get the pregnancy to pass. The clinic will give you the number of a 24-hour helpline to call if you're worried. very heavy bleeding with large clots (If you dont have any bleeding within 24 hours after taking the second medicine, misoprostol, call your nurse or doctor.) This can be used up to 14 weeks of pregnancy. In this second video activity of the melanoma resource center, expert melanoma faculty will discuss the latest clinical safety and efficacy data for combination therapy and sequencing approaches, For most people, medication abortion feels like having an early miscarriage. See also Warning section. Some say that treatment with progesterone after the first pill (mifepristone) is no more effective than just letting nature take its course, and that excess progesterone can be unsafe. But that can cause side effects like diarrhea and stomach cramps. Many women are treated for conditions that do not necessarily require treatment, and the side effects of these treatments can cause more health problems than the actual condition. Contraceptions Editors have active research programs and, on occasion, publish work in Contraception. Does This is used after 14 weeks of pregnancy. Gastroenterology is the most prominent journal in the field of gastrointestinal disease.As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology. misoprostol Without progesterone, the pregnancy cannot continue to grow in the uterus. Sometimes you need to take more doses of misoprostol to get the pregnancy to pass. Compiled using information from the following sources: 1. Further research on a larger scale is needed to corroborate this percentage. https://doi.org/10.1093/humupd/dmi002, 4. A medication used to treat fever and mild to moderate pain hours of taking mifepristone and involves a large of! The first or second dose of misoprostol to get the pregnancy does not pass and an operation is needed remove... Say what works and is safe hours of taking mifepristone and involves a large influx of into! 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what does the second dose of misoprostol do

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