It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the invention. It is the intent of the applicant(s) that all publications, patents and patent applications referred to in this specification are to be incorporated in their entirety by reference into the specification, as if each individual publication, patent or patent application was specifically and individually noted when referenced that it is to be incorporated herein by reference. Example 15. The target platelet count for safe cesarean delivery is conventionally set at > 50 109/L, and this is the threshold we use in our practice. In some embodiments, the system allows automatic machine learning as new data sources are added, and new data is collected, and the predictive algorithms are recalibrated and reselected using the expanded, and hence more reliable, data. Cyclosporine A has not been associated with significant toxicity to mother or fetus during pregnancy when used for inflammatory bowel disease,28 but there is no published experience on its use in ITP in pregnancy and it should be considered only when other safe second-line agents have failed. If the past medical history suggests frequent infections, quantitative immunoglobulin testing may be appropriate.14 If available, review of preexisting laboratory data may reveal abnormalities that preceded the pregnancy or were present only during a prior pregnancy. Never stop taking a prescribed medication unless your healthcare provider has told you to do so. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. In some embodiments, similarly to above, also subject that are prone to frequent sports events will receive a higher score. Whats the difference between BV and a yeast infection? Early diagnosis of TTP/HUS is essential to institute treatment promptly because most fatal events occur within 24 hours from presentation in untreated subjects.69 Any patient with thrombocytopenia and microangiopathic hemolytic anemia in the absence of any obvious precipitating condition should be classified as TTP/HUS. In some embodiments, physical proximity data of a subject with other subjects is calculated by including one or more of: 1. In some embodiments, vaccines are all compounds as disclosed in in the website of the World Health Organization (https://www[dot]who[dot]int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines), which are all incorporated herein by reference, and which are optionally provided (e.g., as a kit) with software such as described herein and/or provided with instructions for use targeting potential super spreaders detected, for example, using methods and apparatus as described herein, and include the following: 28 candidate vaccines in clinical evaluation. In some embodiments, potential superspreaders are identified according to a score in relation to a predetermined score generated by the system. Prolactin is a hormone thats responsible for lactation, certain breast tissue development and milk production. In most cases, it is an acquired disorder because of autoantibodies neutralizing ADAMTS13 activity.65 VWF-cleaving protease deficiency can also occur in DIC, HUS, preeclampsia, and HELLP.66 However, a severe deficiency (< 5% of the activity in normal plasma) appears to be specific for TTP.67, HUS is a more heterogeneous disease. Example 47. Example 40. Actor Chris Hemsworth revealed that he has learned from a recent genetic test that he has a high Alzheimer's risk. In some embodiments of the invention, as the device calculates the person's score, it may generate warning to the device owner to avoid or reduce certain behavior. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. It should be understood that other scales can be used, like heat-map scoring, decimal order scales, etc., all of which are included in the scope of the invention. Conflict-of-interest disclosure: R.S. In addition, about 5% of COVID-19 patients experience complications including septic shock, acute respiratory distress syndrome (ARDS), acute cardiac or kidney injury, and disseminated intravascular coagulation (DIC). What are the most probable etiologies of her thrombocytopenia? As a rule of thumb, developing a platelet count < 100 109/L early in pregnancy, with declining platelet counts as gestation progresses, is most consistent with ITP. Example 45. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. The score may be normalized to the period in which the score is collected. I get so nervous especially since this is my first pregnancy, Im taking oral flagyll! In some embodiments, if a certain subject meets people that were identified as superspreaders, this will influence the score by increasing their score, also when compared to subjects that do not meet superspreaders and/or regular people. In some embodiments, potential superspreaders are identified from a population before critical groups have been excluded. A 36-year-old woman, gravida 2 para 2 (G2P2), with a history of ITP since age 28 asks whether she can safely become pregnant again. In some embodiments, vaccine potency is a quantitative measure of the specific ability of the vaccine product to achieve an intended biological effect defined in a suitable biological assay based on the attribute of the product that is linked to the relevant biological properties. Example 19. The term consisting essentially of means that the composition, method or structure may include additional ingredients, steps and/or parts, but only if the additional ingredients, steps and/or parts do not materially alter the basic and novel characteristics of the claimed composition, method or structure. WebAn aspect of some embodiments of the invention relates to system and methods for anonymously selecting subjects for treatment against an infectious disease caused by a pathogen, comprising: 1. a plurality of electronic devices configured with instructions to generate an ID, when in proximity of another such electronic device, one or both of transmit The system according to any one of examples 65-72, wherein said physical proximity information is physical proximity data received by means of electronic positioning data of said subject. Optionally, the mobile device is used to broadcast, optionally in an anonymous manner, the score, so that, it may be determined, for example, by a central computer, the distribution of scores across the population. Transfusion guidelines for neonates and older children. Example 19. The method according to any one of examples 1-32, wherein said disease results in influenza like symptoms. The method of example 15, wherein said one or more electronic devices are one or more of a smartphone, a tablet, a smartwatch and a dedicated electronic device. Before explaining the invention, the notion of herd immunity should be explained. The present invention, in some embodiments thereof, relates to methods and systems of prioritizing vaccination/treatment and, more particularly, but not exclusively, to methods and systems of prioritizing vaccination/treatment in a pandemic situation. In some embodiments of the invention, update is at end of the day, which may allow aggregating multiple meetings with a same person. She completed her residency at Hofstra Northwell School of Medicine in New Hyde Park. Example 68. In some embodiments, the nature of a location means if it is in a closed place, if it is in an open space, if it is indoors, if it is outdoors, quality of ventilation or any combination thereof. The method according to example 4, wherein said score relates to a predicted likelihood of a group of subjects transmitting said pathogen based on said physical proximity information, and said physical proximity information is a first score component used for said generating said score. 100% Purity Guaranteed: Our pharmaceutical grade Boric Acid is a natural solution for yeast and other issues, made in a facility right here in the USA to ensure a safe and effective formula for BV. ; and. Please check for further notifications by email. Key Findings. The method according to any one of examples 1-27, wherein said virus is a corona virus. PATENTED CASE. Just to give you a heads up, I did develop a yeast infection pretty soon after the BV cleared up. flu, COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS, Computing arrangements based on specific mathematical models, ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment, Security arrangements; Authentication; Protecting privacy or anonymity, Protecting privacy or anonymity, e.g. Women can develop BV regardless of whether theyre sexually active. If you are pregnant or breastfeeding. In this manner, the device can increase or decrease the risk score and/or priority of vaccination, without any central authority being aware of the person's activities. The method according to any one of examples 34-58, wherein said virus is MERS-CoV. The platelet count was 90 109/L at term, and she delivered a healthy neonate with a platelet count of 125 109/L. Her mother had a low platelet count during pregnancy as well, whereas a sister and cousin both had normal platelet counts and history of normal deliveries. The process of encrypting and decrypting messages optionally involves keys. Although relatively safe in pregnancy, prednisone can increase weight gain, induce hyperglycemia, exacerbate hypertension, and contribute to adverse pregnancy outcome.20 A Cochrane meta-analysis has clearly established the beneficial effects of a single course of antenatal corticosteroids (24 mg of betamethasone or dexamethasone, over 2 days) given before 34 weeks of pregnancy to accelerate fetal lung maturation when preterm delivery is imminent.21 Another meta-analysis indicates a 3.4-fold increase in risk of oral cleft among infants with first trimester exposure to steroids.22. As in the nonpregnant patient, testing for antiplatelet antibodies is of no value in the diagnosis of ITP in pregnancy, it is neither sensitive nor specific, nor is it predictive of neonatal thrombocytopenia.15,16 Type 2B VWD should be included in the differential diagnosis of thrombocytopenia during pregnancy, especially in women with a personal or family history of abnormal bleeding, or if therapy for ITP is ineffective (Table 3). Your central nervous system, immune system, uterus and mammary glands are also capable of producing prolactin. Example 30. They tested for it and prescribed clindomycn cream which I highly recommend its just one dose and done! American College of Obstetricians and Gynecologists. How did you know you had it? An aspect of some embodiments of the invention relates to prioritizing vaccinations and/or prophylactic treatments in a pandemic event by identifying potential superspreaders. Lloyd-Smith et al. This could be due to the statins inhibiting the Splenectomy may induce a remission and has been reported to be associated with few complications if performed during the second trimester,29,30 when risks of anesthesia to the fetus are minimal and uterine size will not complicate the procedure. The greater the proportion of immune individuals in a community, the smaller the probability that non-immune individuals will come into contact with an infectious individual, helping to shield non-immune individuals from infection. Make sure you take a vaginal probiotic. Delivery is recommended for women who do not respond to plasma exchange.66 Renal failure may require supportive care with dialysis. called . Centers for Disease Control and Prevention (CDC). WebBrowse our listings to find jobs in Germany for expats, including jobs for English speakers or those in your native language. In some embodiments, IDs are exchanged between electronic devices when in proximity to each other (e.g., to indicate a potentially infectious meeting of the device holders). For example, the term a compound or at least one compound may include a plurality of compounds, including mixtures thereof. In some embodiments, historical medical data of each individual is assessed to provide a score. Therapy late in gestation is generally based on the risk of maternal hemorrhage at delivery (see next section). If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. 2005-2022 Healthline Media a Red Ventures Company. Still, some research suggests that men can spread BV or similar bacterial infections to female partners. In the context of this document, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. In some cases, you may not be able to pull back your foreskin because the skin is too swollen. The system according to any one of examples 64-77, wherein said generating a score further comprises a second score component based on said predicted likelihood of said subject contracting said pathogen based on said physical proximity data. Serum transaminase elevations (values that may exceed 1000 IU/L) are a constant feature. The HELLP syndrome affects 10%-20% of women with severe preeclampsia, but 15%-20% of patients do not have antecedent hypertension or proteinuria.51 Criteria for the diagnosis of HELLP syndrome have been published by Sibai and include hemolysis (abnormal peripheral smear, LDH > 600 U/L, or bilirubin > 1.2 mg/dL), aspartate aminotransferase > 70 U/L, and a platelet count < 100 109/L.52 The Martin et al criteria are less stringent and include an LDH > 600 U/L, an aspartate aminotransferase > 70 U/L and a platelet count < 150 109/L.53 A partial form of the disease among women with severe preeclampsia has been described, in which only 1 or 2 of the 3 components of the syndrome are present.54 Approximately 70% of women with HELLP have evidence of the syndrome antepartum (the majority of cases are diagnosed at 28-36 weeks of gestation) and 30% develop it postpartum.55, Hemolysis has the typical features of microangiopathic hemolytic anemia, including the presence of red cell fragments (schistocytes), elevated serum bilirubin (> 1.2 mg/dL), low serum haptoglobin levels ( 25 mg/dL), and elevated LDH ( 600 IU/L) levels. Optionally, such learned behavior is maintained in privacy and/or collected in an anonymous manner or processed as it is collected, to preserve anonymity. Optionally, if the persons met by a user are vaccinated or otherwise determined to be immune, such contacts may not count and/or be weighted lower. Web1444 S Entertainment Ave. Ste 410. Treatment of thrombocytopenia in these patients must always be balanced with the risk of thrombosis. All rights reserved. The term consisting of means including and limited to. Coagulation abnormalities are unlikely if the count is > 100 109/L.50 Transaminases and LDH levels may be elevated, although less than seen in the HELLP syndrome. In some embodiments, evaluations and models utilize one or more of neural networks, machine learning and dedicated simulations. The invention also includes embodiments, which include fewer than all the features in an example, and embodiments using features from multiple examples, also if not expressly listed below. In conclusion, thrombocytopenia is a relatively common occurrence in pregnancy. Here are 7 of the best over-the-counter yeast infection pills, creams, gels, and treatments. The immune thrombocytopenia syndrome: a disorder of diverse pathogenesis and clinical presentation. Example 28. Mayo Clinic Staff. In some embodiments, identified potential superspreaders having the highest score are vaccinated (or provided with prophylactic treatments) first. Balanitis is more common in men who have foreskin. Over 5 years of treatment statins result in 75 cases of diabetes, 7.5 cases of bleeding stroke, and 5 cases of muscle damage per 10,000 people treated. Example 97. Symptoms commonly include a thick, white vaginal discharge, or itching. The system according to any one of examples 69-75, wherein said electronic positioning data is one or more of electronic geographical positioning data of said subject, electronic proximity positioning data of said subject relative to other subjects. Your post will be hidden and deleted by moderators. Higher-than-normal levels of prolactin in your blood can cause certain symptoms, such as irregular periods, infertility and erectile dysfunction. Optionally, a network connection is provided as well. I ordered this pre probiotic for pregnancy from this brand Needed. In some embodiments, models and simulations are run in dedicated computers, for example, to assess the potential progression of the treatments and the probable time to reach herd immunity and/or select values for various parameters. Example 25. The method according to any one of examples 34-51, wherein said physical proximity information comprises historical location data. Learn what to look for, and when. In some embodiments, vaccines contain a microorganism or virus in a weakened, live or killed state, or proteins or toxins from the organism. In some embodiments of the invention, the score is calculated after all contact events are collected, for example, based on an analysis of a contact-network to identify individuals, which, if vaccinated, will best stop infection. In some embodiments, individual data arriving from each user is coupled with their health information (sick, vaccinated, recovered, etc.) ( CDC ) involves keys prolactin is a corona virus Hofstra Northwell School of in. Learned from a population before critical groups have been excluded means including and limited to regardless of theyre! Revealed that he has a high Alzheimer 's risk of diverse pathogenesis and clinical presentation said virus MERS-CoV! Especially since this is my first pregnancy, how to treat bv while pregnant taking oral flagyll of means including and to! She completed her residency at Hofstra Northwell School of Medicine in new Hyde Park a common. 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