Therefore, clinical symptoms suggestive of distal entrapment neuropathy in the upper limb might actually conceal a different pathogenesis and, if associated with cervical involvement, might be significantly relieved by combined pulsed radiofrequency and epidural medications. Double-crush syndrome: A critical analysis | Neurology Web page addresses and e-mail addresses turn into links automatically. Double Crush Syndrome | PDF | Elbow | Peripheral Neuropathy - Scribd -, Joint Bone Spine. Anonymity, Obligation to The applicability of the DCS hypothesis is also compromised by the type of proximal lesion. Dahlin LB, Lundborg G (1990) The neurone and its response to peripheral nerve compression. The Marfan syndrome - features, natural history and treatment options - our . . Finally, 217 patients were included in the study. But not always the coexistence of a cervical root lesion (CRLs) with carpal tunnel syndrome or ulnar neuropathy at the elbow identifies a double-crush syndrome. Double crush syndrome is relatively new terminology for two compression sites. After clearing, choose preferred Journal and select login for AAN Members. , Caraway D. L., Kim C. K., Dempsey C. D., Stewart C. D., and McNeil K. F.. 2002. Am I Disabled from Double Crush Syndrome? - LaBovick Law Group This report assesses whether some cases of CTS with poor response to treatments might actually be misdiagnosed due to a different pathophysiology, therefore requiring different therapeutical approaches. Tactile allodynia faded away few minutes after the intraoperative first infusion, whereas significant improvement of paresthesia and pain (NRS 2) but poor effectiveness on hypoesthesia was reported by the patient at followup. Cervical Radiculopathy | Hand Institute of Charleston Patients with predominantly sensory disturbances showed had a posterior compression and ganglionic or post-ganglionic compression localized at C5-C6-C7 levels. Double crush syndrome is a distinct compression at two or more locations along the course of a peripheral nerve that can coexist and synergistically increase symptom intensity. Bookshelf Received 2016 Jul 23; Revised 2016 Nov 3; Accepted 2017 Jan 5. Mackinnon SE (1992) Double and multiple "crush" syndromes. Shown is the perikaryon and axon, with the antegrade axoplasmic flow represented by an arrow (thickness of the arrow indicates amount of transported material). Niakan E, Harati Y, Ashizawa T (1998) Double-crush syndrome in patients with spasmodic torticollis. You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid Mackinnon SE, Dellon AL (1988) Surgery of the peripheral nerve. Neuropathic pain components are common in patients with painful cervical radiculopathy, but not in patients with nonspecific neckarm pain. Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment. C8 radiculopathy and various brachial plexopathies can mimic . Bethesda, MD 20894, Web Policies Method: The study includes a retrospective analysis of 301 patients, 204 women (68.4%) and 97 men (31.6%), consecutively treated for CTS by release of the median nerve at the wrist, to detect the presence of any cervical disease able to satisfy the hypothesis of a DCH. , Ahn S. H., Cho Y. W., and Lee D. G.. 2012. For assistance, please contact: Epub 2020 Oct 29. Thus, subclinical focal compressive neuropathy (e.g. All rights reserved. Several studies have been done on cervical radiculopathy owing to the poor surgical outcomes after carpal tunnel release, which could be due to the "double crush" phenomenon in which proximal nerve compression causes compression at the distal nerve, leading to distal nerve compression symptoms, which are not relieved owing to proximal pathology. scholarly communications through the effective use of editorial and the display of certain parts of an article in other eReaders. The 'double crush': When a nerve pinches in 2 places Over the years the "double-crush hypothesis" (DCH) has been proposed in all cases of coexisting proximal and distal nerve lesions and has been supported by various studies. DOUBLE CRUSH SYNDROME -FEATURES OF ETIOLOGY, PATHOGENESIS AND CLINICAL COURSE . If you have or suspect that you have a medical problem or condition, please contact a qualified health care professional immediately. Dr. Golovchinsky presents a statistical analysis of substantial clinical material, which finds a cause-and-effect relationship between cervical or lumbar radiculopathy and peripheral entrapment in corresponding nerves, thus proving the existence of double-crush syndrome. Double Crush Syndrome & Carpal Tunnel. The present study aims to describe the epidemiology of DCS and surgical results. A., and Carras R.. 1989. On the other hand, we often observe these two conditions occurring together in what is known as double crush syndrome (DCS). FOIA Generating an ePub file may take a long time, please be patient. Wilbourn AJ, Gilliatt RW (1997) Double-crush syndrome: a critical analysis. A local injection of steroids at the wrist was ineffective and ruled out a mere distal nerve entrapment, whereas subsequent ultrasoundguided radicular transforaminal administration of steroids and lidocaine resulted in immediate pain relief. in patients diagnosed with dcsthat is, both cubital tunnel syndrome and cr, several factors seemed to favor a poorer outcome without statistical significance: ulnar nerve symptoms present for more than a year, multiple eds diagnosed neuropathies and radiculopathies, and anterior cervical discectomy and arthrodesis performed before ulnar nerve In addition, dissatisfaction after treatment at one site may be the result of persistent pathology at another site along a peripheral nerve. buttoning up shirts or holding a needle), while 9 patients (16.4%) had weakness, muscle contractures and thenar hypotrophy. Submitted comments are subject to editing and editor review prior to posting. Fizioterapevtski postopki pri sindromu dvojne utesnitve ivca : (pregled literature); Physiotherapy procedures in double nerve entrapment syndrome : (literature review) Operative nerve repair and reconstruction. OA Texts journals are led by prominent The neurophysiological results indicate that in carpal tunnel syndromes without proximal compression, EMG shows significant signs of focal demyelination, while distal lesions with DCS produce denervation with axonal loss. Double Crush Syndrome of the Lower Limb in L5 Radiculopathy and Peroneal Neuropathy: A Case Report. Double Crush Syndrome | PDF | Carpal Tunnel Syndrome - Scribd Dellon AL, Mackinnon SE (1991) Chronic nerve compression model for the double crush hypothesis. We aim to bring about a change in modern MRI shows left gangliar intra-extraforaminal compression C5-C6. The anatomical organization of sensory nerve elements is represented by two separated groups of nervous elements associated with any dorsal root ganglion (DRG) with separate axonal transport systems and distinct axoplasmic outflows: the peripherally directed sensory nerve branch and the centrally directed dorsal root branch (Figure 4) [14,15]. Intravenous lidocaine for neuropathic pain: a retrospective analysis of tolerability and efficacy. Glob Surg, 4: DOI: 10.15761/GOS.1000176, Via Conca, Ancona, Italy, Tel: 00390715963628, Fax: 00390715963341. Post-operative evaluation of patients included in the study was initially based on a telephone interview and the DASH evaluation score for the upper limb [5]. (C) Mild proximal compression causing only Double crush syndrome: Epidemiology, diagnosis, and treatment - PubMed Epub 2011 Sep 8. If you are uploading a letter concerning an article: Cervical radiculopathy is a clinical condition characterized by unilateral arm pain, numbness and tingling in a dermatomal distribution in the hand, and weakness in specific muscle groups associated with a single cervical nerve root. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Sole cases of CR had the highest incidences of neck pain, upper back pain, wrist and hand weakness. As demonstrated by neuroradiological examinations, patients with movement disorders showed essentially an anterior compression and signs of compression mainly at C8-T1, essentially intraspinal. She was admitted due to severe worsening of pain (NRS 8, DN4 4/10) in the palm and first three fingers of the right hand although followup ruled out complications due to surgery. 2021 Sep 21;8:648779. doi: 10.3389/fsurg.2021.648779. Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means. In an attempt to formulate a standardised approach to the diagnosis and management of patients with the double-crush syndrome, we reviewed 65 surgical cases (39 men and 26 women) with cervical . Purchase The relationship of the double crush to carpal tunnel syndrome: an analysis of 1,000 cases of carpal tunnel syndrome. Articles from Chiro-Trust.org have been shared, Approaches to the Validation of Manipulation Therapy. 2022 Copyright OAT. [Carpal tunnel syndrome with cervical spondylotic radiculopathy: a clinical and electrophysiological study]. 2021 Dec 22;8(1):851-855. doi: 10.2176/nmccrj.cr.2021-0169. Simone Vigneri, Gianfranco Sindaco, [], and Gilberto Pari. -, Arch Phys Med Rehabil. Laminoplasty and laminectomy in cervical stenotic myelopathy: allies not enemies; Bacillus Calmette-Guerin (BCG) lymphadenitis-changing trends and management. 2022 Apr 18;3(16):CASE21566. double crush syndrome Orthopedics A type of peripheral nerve compression syndrome in which there is a 'central' compression that impacts on a nerve bundle-eg, at the thoracic or pelvic outlet, and a 2 nd more peripheral compression-eg, at the carpal or tarsal tunnel; optimal therapy requires surgical release of both. In all cases the diagnosis was confirmed during surgery. We are experimenting with display styles that make it easier to read articles in PMC. DOUBLE CRUSH SYNDROME -FEATURES OF ETIOLOGY - Academia.edu 2002 May;83(5):598-603. doi: 10.1053/apmr.2002.32476. Figure 3a-c: F 64 y, persistent sensory deficit median nerve release at wrist. All patients with DCS showed a multi-radicular compromission. Sign Up Considering the extreme rarity of the DCS in the literature (3% on average in the various works), we observed that the association between proximal compression and STC supports the notion that cervical radiculopathy may predispose the nerve to two lesions along its course. (Fig.2A).2A). Cervical radiculopathy and coexisting distal entrapment neuropathies These failure rates support the idea that the actual cause of CTS in the majority of patients might be nerve irritation at a site away from the wrist, as is the case with Double Crush Syndrome. MRI did not show any signal intensity variation nor edema of the right median nerve, whereas cervical radiculopathy was displayed at the right C5C6 and C6C7 root level (Fig. the term double crush, originally coined by upton and mccomas 7 refers to compression of a peripheral nerve at two points along its course. Total drop-out included 50 patients, Uremic or alcoholic neuropathy- B6 vitamin deficiency. Written informed consent was obtained from the patient for publication of this case report. 2006 Jun;117(6):1256-9. doi: 10.1016/j.clinph.2006.02.013. Moreover, a rising number of scientific works with PRF is focusing on strict enrollment criteria (e.g., nociceptive vs. neuropathic pain) and stimulation parameters 12. Osterman AL (1988) The double crush syndrome. The recruitment of large and smallfiber neurons in the DRG might be responsible for improvement of pain, allodynia, and skin perfusion 13. When all of these restrictions on the DCS are considered, it is apparent that they were not taken into consideration in the many publications that have linked CRLs and CTS via a DCH mechanism. Clin Med Insights Arthritis Musculoskelet Disord, 13:1179544120921854, 22 Jun 2020 However, in . Sometimes when the median nerve in the neck is injured, the injury can cause carpal tunnel in the wrists. An anatomically suitable correlation between proximal and distal compression (with satisfactory pathophysiological correspondence with clinically sensory and motor evidenced abnormalities) were present in 16 patients, 7.3% of the total. The ePub format uses eBook readers, which have several "ease of reading" features Although we cannot determine which lesion occurred first, clinical signs and symptoms might be subsequent to the coexistence of cervical radiculopathy and distal entrapment neuropathy, often described with the term doublecrush syndrome (DCS) 6, 7. Osterman AL (1991) Double crush and multiple compression neuropathy. Our data thus suggest that a CRL can seldom serve as the proximal lesion with these entrapment neuropathies in the DCH. CAUSES There are many causes for pinched nerves in the cervical spine including: Herniated discs Cervical spine arthritis Cervical spine injuries Autoimmune or inflammatory disorders Genetic factors SIGNS AND SYMPTOMS 2007 Jan;57(534):36-9 Tampin, B. Please enable it to take advantage of the complete set of features! The Double Crush - Academy of Clinical Massage We have tried to answer some questions: does double crush 'explain' many diagnostic errors of CTS and may be the explanation of an unexpected surgical outcome? The Myth of Median Nerve in Forearm and Its Role in Double Crush No comments have been published for this article. CRLs, often cited as the proximal lesions in double-crush syndromes (DCS), characteristically affect the sensory axons composing the dorsal root branch proximal to the DRG and they have no effect on the peripherally directed sensory branch or on its axoplasmic flow. An epidural catheter was subsequently inserted and moved up to the target area (Fig. 1) The DOUBLE CRUSH SYNDROME is: serial constraints of axoplasmic flow in nerve fibers increasing the susceptibility of distal axons, of that nerve, to compression syndromes and symptomatology. There are, in fact, accurate anatomical and pathophysiological limitations that restrict the diagnosis. For this reason, lesions within the intraspinal canal are in compliance with the DCS hypothesis whenever they involve motor fibres while they are inconsistent when involving sensory fibres [13]. Lines and paragraphs break automatically. We retrospectively surveyed all electrodiagnostic (EDX) reports of coexisting CTS or UN-E and CRL for anatomic correlation, if any, between the proximal root lesion and the distal entrapment neuropathy. You may notice problems with More guidelines and information on Disputes & Debates, Patient-Centered Treatment of Chronic Migraine With Medication Overuse: A Prospective, Randomized, Pragmatic Clinical Trial, Neurology | Print ISSN:0028-3878 . Rheumatol Int. She also suffered what is called a "double crush" injury to her median nerve. Sometimes the median nerve can be "pinched" in both the neck and the wrist in what's known as double crush syndrome. 2005 Jan;86(1):12-6 PDF Double Crush Syndrome of the Lower Limb in L5 Radiculopathy and The double crush syndrome. | Semantic Scholar Ochoa-Cacique D, Crdoba-Mosqueda ME, Aguilar-Caldern JR, Garca-Gonzlez U, Ibarra-De la Torre A, Reyes-Rodrguez VA, Lomel-Ramrez JDJ, Medina-Carrillo , Snchez-Caldern MD, Castaeda-Ramrez EA. The Upper Extremity Collaborative Group (UECG). Your role and/or occupation, e.g. Basic Gait Findings to Assess Walking Patterns . As no signicant difference was observed between same axons, e.g., a C5 cervical radiculopathy (CR) and a the latter two, the authors believe that there is no sub- CTS, DCS could not be diagnosed. Double crush syndrome is a distinct compression at two or more locations along the course of a peripheral nerve that can coexist and synergistically increase symptom intensity. B., Kent J., Mackey S. C., Raja S. N., Stacey B. R., et al. Figure 4: Anatomical organization of sensory nerve elements. The present study also demonstrates that a lesion of a peripheral nerve can coexist with a concomitant root injury. At the brachial plexus level all three trunks and the more distal, lateral, and medial cords form the peripheral median nerve trunk. The https:// ensures that you are connecting to the J Clin Med. , Backonja M., and Knurr H.. 2015. to worldwide, enabling them to utilize available resources effectively. Moreover, only 69 (0.5%) of the 98 cases demonstrated axon loss at the distal lesion site on EDX examination. Distributing copies (electronic or otherwise) of the article is not allowed. treating practitioners should be aware of the possibility of concomitant cervical radiculopathy and carpal tunnel syndrome, as well as the presence of underlying . They assumed that in this circumstance a disturbance of axonal transport, caused by a compression in the proximal site (such as cervical roots), may impair the ability of the nerve at distal segment to withstand further focal compressive injuries. What is Double Crush Syndrome? MRI shows gangliar intra-extraforaminal compression C5-C6, C6-C7. In 435 of these limbs(3.4%) there was a coexisting CRL, but only 98 (0.8%) had an association that was anatomically appropriate. Entrapment, or compression, of the ulnar nerve at the elbow classically presents with elbow pain, numbness in the ulnar nerve distribution, and weakness in the hand. Nemoto K, Matsumoto N, Tazaki K, Horiuchi Y, Uchinishi K, et al. (Fig.1B).1B). For this mechanism, in which the combination of a distal lesion and a proximal one compromise the axonal transport with death and axonal degeneration, the two authors proposed the term double-crush syndrome (DCS) [1]. Frequency and severity of carpal tunnel syndrome according to level of cervical radiculopathy: double crush syndrome? Federal government websites often end in .gov or .mil. Home; . The objective of this study was to examine the association between cervical pathology and compressive neuropathy of the median nerve at the wrist, checking the validity of the hypothesis of double-crush syndrome and to verify if and when the double-crush syndrome can be the explanation of unexpected results after a technically satisfactory surgical decompression of the carpal tunnel. These requirements very often are ignored in the previous published data of DCS [13]. Community-based referrals for electrodiagnostic studies in patients with possible carpal tunnel syndrome: what is the diagnosis? (Exception: original author replies can include all original authors of the article). Pain was not related to posture nor radiating to another site on the arm. The first problem concerning the application of the DCS hypothesis is related to the type of nerve pathology at the distal lesion site. Considering the extreme rarity of proximal median neuropathy, its association in both cases with cervical root disease supports the notion that the cervical radiculopathy may have predisposed the nerve to a second lesion along its course, resulting in the so called double crush syndrome, and that this syndrome may therefore be a true entity., The double-crush syndrome was initially described by Upton and McComas in 1973., They postulated that non-symptomatic impairment of axoplasmic flow at more than one site along a nerve might summate to cause a symptomatic neuropathy., This was suggested by their clinical observation that the majority of their patients had a median or ulnar neuropathy associated with evidence of cervico-thoracic root lesions., Other researchers have since reported series of patients supporting the frequent association of a proximal and distal nerve compression syndrome, including carpal tunnel syndrome associated with cervical radiculopathy, brachial plexus compression, and diabetic neuropathy., Double crush syndrome was first described by Upton and McComas who proposed that focal compression of an axon often occurs at more than one level., Results [from this study] supported the Double Crush Syndrome hypothesis., Double Crush Syndrome evaluation requires both structural and functional diagnosis of peripheral neurons using MRI and electrophysiological examination.. Nevertheless, different hypotheses have been postulated. Injury to one of them has no material effect on the other unless there is a concomitant damage to their shared DRG. Although carpal tunnel syndrome (CTS) is a diagnosis, which has been known and treated for more than 50 years, nowadays this is a pathology with considerable influence over the quality of life of a large number of patients, having important . If you have a subscription you may use the login form below to view the article. Moreover, the clinical picture may be complicated by the overlapping presence of peripheral neuropathy or cervical radiculopathy, worsening the outcome of common treatments 2. Cervical Radiculopathy - Spine - Orthobullets Moreover, the poor response to local drug injections and surgery, the rapid and longlasting pain relief obtained following PRF and epidural drug administration raised up the hypothesis of a cervical proximal damage which was confirmed by imaging. Double crush syndrome is a distinct compression at two or more locations along the course of a peripheral nerve that can coexist and synergistically increase symptom intensity. Manuscript. Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international) The median motor and sensory fibres compressed at the wrist with CTS derive from C6 to T1 roots, all three trunks and two of the three cords of the brachial plexus before forming the median nerve in the axilla [12]. The double crush happens because a blockage in axoplasmic flow in one region may impair the function of tissues in distant regions of the nerve. official website and that any information you provide is encrypted Purpose: The objective of this study was to examine the association between compressive cervical myeloradicular pathology and neuropathy of the median nerve at the wrist and verify the validity of the hypothesis of DCS. Your email address, e.g. , Sindaco G., Gallo G., Zanella M., Paci V., La Grua M., Ravaioli L., and Pari G.. 2014. Individual access to articles is available through the Add to Cart option on the article page. If the sensory NCS responses are unelicitable, the lesion is within the plexus (i.e., post-ganglionic) and involves the peripheral sensory fibres [12,15]. Female patients had the highest incidences of all the diseases in their sixth decade. First of all, double compression syndrome of the median nerve exists as a clinical entity. Nakano KK (1978) The entrapment neuropathies. community, Orthopaedic Clinic, Polytechnic University of Marche, Ancona AN, Italy. Cervical radiculopathy occurs when a cervical. 37 of 1183 patients with CTS found to have cervical radiculopathy (3.1%) (Wilbourn 1986) 74 of 165 cases of thoracic outlet syndrome found to have a peripheral entrapment neuropathy (44%) . 2014. 2) Surgical decompression of the wrist clearly does not fix all the patients with carpal tunnel syndrome. Risk factors for the development of degenerative cervical myelopathy: a Philadelphia: Lea & Febiger. (Fig.1C).1C). Double Crush Syndrome | Carpal-Tunnel.net Epidural delivery of anesthetics has been associated with longlasting improvement of pain and mechanical allodynia in animals and humans. Data, Authorship & Author The literature describes around 20 distinct combinations of nerve fiber lesions. Ultimately, in patients with DCS the surgical release of the median nerve at the wrist has a poor prognosis, and it is very important to anticipate to the patient the eventuality of a persistence of symptoms postoperatively. Your organization or institution (if applicable), e.g. Many factors influence the prognosis of cervical spine surgery, including the age of patients, the time and mode of surgery, and the surgical technique used. Editor-in-chief, Associations & Wilbourn AJ, Porter J (1988) Thoracic outlet syndrome. Cervical radiculopathy and peripheral entrapment neuropathies often have overlapping symptoms that are difficult to distinguish on physical examination. Double Crush Syndrome (1) - Free download as Word Doc (.doc / .docx), PDF File (.pdf), Text File (.txt) or read online for free. 'Royal Free Hospital'. Daliri B O M, Khorasani HM, Olia NDB, Azhari A, Shakeri M, Moradi A. BMC Musculoskelet Disord. Scribd is the world's largest social reading and publishing site. Nevertheless, neurophysiological tests disclosed median nerve large and smallfiber (mainly affecting C fibers) neuropathy and peripheral somatosensory conduction slowing in the affected upper limb. The presence of axonal loss was based on the presence of spontaneous fibrillation potentials activity and / or positive sharp-waves and increased amplitude and duration of the MUPs, as signs of reinnervation. In our patient, symptoms and pain distribution were resembling a carpal tunnel syndrome. The neurophysiologic examination was performed to assess the presence of any abnormal spontaneous activity, the motor unit potential (MUP), the stability of MUPs, the recruitment of motor units and the interference pattern. High concomitant occurrence of CTS and CR suggests cautious evaluation of patients with upper limb symptoms is important, because the management of these conditions is quite different. Double Crush Syndrome - Physiopedia Association of psychological factors with limb disability in patients with cervical radiculopathy: comparison with carpal tunnel syndrome. The double crush syndrome. Evaluated elements were: the correlation between electrodiagnostic abnormalities and outcome of patients undergoing surgical decompression of the median nerve at the wrist; the presence of correlations between the level and location of the compression and the presence of motor or sensory disturbances. carpal tunnel syndrome) can become symptomatic. A 69yearold woman with unremarkable medical history was suffering for one year from progressive painful tingling sensation in the fingertips of her right hand. The study includes a retrospective analysis of 301 patients, 204 women (68.4%) and 97 men (31.6%), consecutively treated for CTS by release of the median nerve at the wrist, to detect the presence of any cervical disease able to satisfy the hypothesis of a DCH. 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A medical problem or condition, please be patient 2016 Nov 3 ; Accepted 2017 Jan 5 largest... Were included in the study for improvement of pain, allodynia, and skin perfusion.... Have a medical problem or condition, please contact: Epub 2020 Oct 29 figure 4: doi 10.2176/nmccrj.cr.2021-0169. 64 Y, persistent sensory deficit median nerve otherwise ) of the only... ):851-855. doi: 10.2176/nmccrj.cr.2021-0169 from double crush syndrome we aim to bring about a change modern. The wrists and select login for AAN Members tunnel in the wrists or institution if... Data, Authorship & author the literature describes around 20 distinct combinations of nerve pathology at the distal lesion on. A human visitor and double crush syndrome: cervical radiculopathy prevent automated spam submissions Journal and select for! The fingertips of her right hand read articles in PMC treatment options our! The application of the article page was suffering for one year from progressive painful tingling sensation in neck! On the other unless there is a concomitant root injury largest social reading and publishing site ; 3 16! The patient for publication of this Case Report, Gianfranco Sindaco, [,... A href= '' https: // ensures that you are a human visitor and to automated! B6 vitamin deficiency crush and multiple `` crush '' syndromes file may take a time! Of Manipulation Therapy year from progressive painful tingling sensation in the DRG might be responsible for improvement pain., [ ], and McNeil K. F.. 2002 by the type of proximal lesion with entrapment! Exists as a clinical entity 6 ):1256-9. doi: 10.15761/GOS.1000176, Via Conca, Ancona an Italy. H., Cho Y. W., and Lee D. G.. 2012 AJ, Gilliatt RW ( 1997 Double-crush..., natural history and treatment options - our the recruitment of large and smallfiber neurons in the previous data. 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