2022 Feb;74:101551. doi: 10.1016/j.arr.2021.101551. Leisure time physical activity (LTPA) was assessed using Godin physical activity form, and total LTPA dose was measured by metabolic equivalents (METs)-minutes/2-weeks. The Atherosclerosis Risk in Communities study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute (NHLBI), NIH, Department of Health and Human Services contract numbers HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, and HHSN268201700005I (R01HL087641, R01HL059367, and R01HL086694); National Human Genome Research Institute contract U01HG004402; and NIH contract HHSN268200625226C. Among all the subjects, with improved levels of physical activity, the risks of dementia significantly decreased. Association of ideal cardiovascular health at age 50 with incidence of dementia: 25 year follow-up of Whitehall II cohort study. We hypothesized that higher LS7 would be associated For this prospective cohort study, we included REasons for Geographic And Racial Differences in Stroke (REGARDS) participants aged 45+ who had normal global cognitive status at baseline and no history of stroke (N=17761). Decreased incidence rate of dementia was observed with improved levels of LS7 metrics (Table 2). Diagnosis of dementia in a heterogeneous population. From the Chinese Alzheimers Biomarker and LifestylE (CABLE) study, 1106 cognitively normal participants were enrolled. Ogino E, Manly JJ, Schupf N, Mayeux R, Gu Y. Traveling can be a great, Youll want to pack light, but you dont want to leave anything important behind. Written informed consent was provided by all the participants. bIntermediate and ideal categories for smoking were combined because of low numbers in the intermediate category. Figure 2. See this image and copyright information in PMC. Livny A, Ravona-Springer R, Heymann A, Priess R, Kushnir T, Tsarfaty G, et al. Gu Y, Beato JM, Amarante E, Chesebro AG, Manly JJ, Schupf N, et al. Abbreviations: APOE-4, apolipoprotein E genotype 4; LS7, Lifes Simple 7; SD, standard deviation; %, proportion. organization. 2014;3:e000635, Achieving ideal cardiovascular and brain health: opportunity amid crisis: presidential address at the American heart Association 2010 Scientific Sessions, Vascular risk factors and cognitive impairment in a strokefree cohort, Promising strategies for the prevention of dementia, Defining and setting national goals for cardiovascular health promotion and disease reduction: The American Heart Association's strategic impact goal through 2020 and beyond, Life's simple 7 and risk of incident stroke: the Reasons for Geographic and Racial Differences in Stroke study, Ideal cardiovascular health predicts lower risks of myocardial infarction, stroke, and vascular death across whites, blacks, and hispanics: The Northern Manhattan Study, Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidence, The reasons for geographic and racial differences in stroke study: objectives and design, A databased approach to diet questionnaire design and testing, Implications of increased creactive protein for cardiovascular risk stratification in black and white men and women in the us, Calculating Cornell voltage from nonstandard chest electrode recording site in the Reasons for Geographic And Racial Differences in Stroke study, Sixitem screener to identify cognitive impairment among potential subjects for clinical research, The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). We do not capture any email address. The proportion of participants classified as having ICI on the 3test measure was similar by age, sex, race, and education category because those variables were used to define the stratumspecific cutoff scores for impairment. Baseline Life's Simple 7 components were each categorized as ideal, intermediate, or poor. Depression status (yes, no) was assessed via the 10-item Centre for Epidemiological Studies Depression Scale (CES-D), and a cut-off score of 4 was used to identify individuals with major depression [31]. doi = "10.1212/WNL.0000000000200520". Whether you want a movie night, party or barbecue, weve got you covered. A recent study did find AD patients who were APOE 4 carriers benefitted more from the exercise intervention by preservation of cognitive performance [39]. Dementia prevention, intervention, and care. We help visitors save more money to spend on other aspects of their visit to Lombardy. Customer Service Associations between LS7 scores and incident dementia. Incident dementia was identified when the subjects were firstly clinically diagnosed with dementia during the follow-up study among those with a previous diagnosis with no dementia. Mean Life's Simple 7 score was slightly lower among participants who were excluded from analyses because they had no followup 3test measure assessment (7.3 points). Health behavior score and biological health factor score were divided into tertiles. Its a question. The incident dementia was identified based on the standard criteria and consensus diagnosis. Students also receive a special discount if they present to us a student ID or an enrolment statement. Trial, Heart Disease and Stroke Statistics2022 Update: A Report From the American Heart Association, Heart Disease and Stroke Statistics2021 Update, Change in Lifes Simple 7 Measure of Cardiovascular Health After Incident Stroke, Racial, Ethnic, and Geographic Disparities in Cardiovascular Health Among Women of Childbearing Age in the United States, Association of Socioeconomic Status With Ideal Cardiovascular Health in Black Men, Ideal cardiovascular health in women with systemic lupus erythematosus: Association with arterial stiffness, inflammation, and fitness, Demenzerkrankungen Prvalenz, Bedeutung und Implikationen fr die Prvention und Gesundheitsfrderung, Relation of Atrial Fibrillation to Cognitive Decline (from the REasons for Geographic and Racial Differences in Stroke [REGARDS] Study), Further understanding of ideal cardiovascular health score metrics and cardiovascular disease, The Relationship Between Cardiovascular Health and Rate of Cognitive Decline in Young-Old and Old-Old Adults: A Population-Based Study, Disparities in Cognitive Impairment With Anticholinergic Drug Use, Age at menarche and cardiovascular health: results from the NHANES 1999-2016, A cross-sectional analysis of racial differences in accelerated aging and cognitive function among patients with atrial fibrillation: The SAGE-AF study, Cardiovascular Health Metrics in Patients Hospitalized with an Acute Coronary Syndrome, The link between blood pressure and Alzheimer's disease, Does serum vitamin D level affect the association between cardiovascular health and cognition? Long-term Variability in Glycemic Control Is Associated With White Matter Hyperintensities in APOE4 Genotype Carriers With Type 2 Diabetes. Dhana K, Evans DA, Rajan KB, Bennett DA, Morris MC. 1-800-AHA-USA-1 Symptoms, Types, and Diagnosis. REGARDS indicates REasons for Geographic And Racial Differences in Stroke; y, year. BMI was calculated, using measured weight and height, as weight in kilograms divided by height in meters squared. The Simple 7 include four modifiable behaviors (not smoking, healthy weight, eating healthy and being physically active) and three biometric measures (blood pressure, cholesterol and blood sugar). These seven factors are classified into three categories: ideal, intermediate and poor. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. WebINTRODUCTION: There is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population. Crane PK, Walker R, Hubbard RA, Li G, Nathan DM, Zheng H, et al. Flow chart of REGARDS participants. Its accessible through the Montenapoleone Fashion District. Adjusted ORs for ICI were nearly the same for the middle (OR, 0.65; 95% CI, 0.52, 0.81) and highest tertile (OR, 0.63; 95% CI, 0.51, 0.79) of Life's Simple 7 score, relative to the lowest tertile (Table3). WebIntroduction There is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population. Life's Simple 7 is a new metric based on modifiable health behaviors and factors that the American Heart Association uses to promote improvements to cardiovascular health (CVH). Levels of insulin, glucose, and Homeostatic Model Assessment-Insulin Resistance were related with increased AD risks or lower cognitive function among APOE-4 negative but not 4 positive subjects based on data from prospective cohort [5, 44] and cross-sectional studies [45], which were consistent with our findings. C.R. doi: 10.1161/JAHA.121.022959. We examined participant characteristics by Life's Simple 7 score tertile and by ICI status. In addition, improved levels of LS7 scores and the LS7 components of smoking and blood glucose were significantly associated with reduced dementia risk in the APOE-4 allele noncarriers but not in carriers. Levels of total cholesterol, glucose, and HbA1c were measured according to standard research procedures [27]. Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study. APOE-4 allele contributes to neuronal degeneration through the acceleration of A deposition and neurotoxicity [35]. Our staff are also friendly and enjoy helping visitors to have a comfortable stay with us. Life's Simple 7 likely to be associated with dementia risk reduction in both midlife and older age groups BMJ. Before We hypothesized that better Life's Simple 7 scores are associated with lower incidence of cognitive impairment. However, ICI was more common with lower income, residence in the stroke belt, and presence of CVD (Table2). We read with interest the recent study1 by Sabia et al showing that adherence to Lifes Simple 7 ideal cardiovascular health recommendations in midlife (age 50 years) was PLoS Med. Among EA participants, higher LS7 scores were consistently associated with lower risk of dementia across quintiles of GRS, including the highest quintile (HR per point 0.91, 95% CI 0.87, 0.96). Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia. If you are unable to import citations, please contact We derived midlife LS7 scores and generated genetic risk scores (GRS) using genome-wide summary statistics of Alzheimer disease, which have been used to study the genetic risk for dementia. Better The association was also similar for different ages, women and men, and levels of education (data not shown). official website and that any information you provide is encrypted As mechanisms underlying the modification effects of APOE-4 allele are not yet fully understood, more biological measurements may help better understand the relevant mechanisms. We derived midlife LS7 scores and generated genetic risk scores (GRS) using genome-wide summary statistics of Alzheimer disease, which have been used to study the genetic risk for dementia. 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