DE819405C - Verfahren zur Herstellung von bifunktionellen Toxicology and Carcinogenesis Studies of Vinylidene Chloride in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2015 Long-Term Carcinogenicity Bioassay of 4'-(Chloroacetyl)-acetanilide for Possible Carcinogenicity (CASRN 140 The main target users are workers and those responsible for occupational safety and health. Molecular Formula. Organic Process Research & Development | Ahead of Print Chloroacetyl chloride Ranolazine is the only antianginal agent without changing heart rate or blood pressure. 55589-62-3) in FVB/N-TgN(v-Ha-ras)Led (Tg.AC) Hemizygous Mice and Carcinogenicity Studies of Acesulfame Potassium in B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Feed Studies), Toxicology Studies of Pentaerythritol Triacrylate (Technical Grade) (CASRN 3524-68-3) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies), Organotin and Total Tin Levels in Danish Women of Reproductive Age, Bioassay of 2,4-Diaminoanisole Sulfate for Possible Carcinogenicity (CASRN 615-05-4), Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (Phenytoin) in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in B6C3F1 Mice (Inhalation Studies), Toxicology and Carcinogenesis Studies of Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies), Toxicology and Carcinogenesis Studies of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4) in Female Harlan Sprague-Dawley Rats (Gavage Studies), Comparative Toxicity Studies of Allyl Acetate, Allyl Alcohol and Acrolein Administered by Gavage to F344/N Rats and B6C3F1 Mice, Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice, Toxicology and Carcinogenesis Studies of Gallium Arsenide (CASRN 1303-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Bioassay of Fenthion for Possible Carcinogenicity (CASRN 55-38-9), Toxicology and Carcinogenesis Studies of Promethazine Hydrochloride in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Chlorinated Trisodium Phosphate (CASRN 56802-99-4) in B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (Major Component 79%-85% Curcumin) in F344/N Rats and B6C3F1 Mice (Feed Studies), Carcinogenesis Bioassay of C.I. deren Hydrazinsalz. US2993895A US795352A US79535259A US2993895A US 2993895 A US2993895 A US 2993895A US 795352 A US795352 A US 795352A US 79535259 A US79535259 A US 79535259A US 2993895 A US2993895 A US 2993895A Authority US United States Prior art keywords benzhydrylmorpholine salts compounds grams mole Prior art date 1959-02-25 Legal The mixture was extracted with dichloromethane and the organic layer was concentrated under vacuum at 60 C. to get 39.4 g of N-(2,6-dimethylphenyl)-1-piperazinylacetamide having a yield of 63%. Tetrachloroethylene (CASRN 127-18-4) - No report issued. Acid Orange 10 (CASRN 1936-15-8) in F344 Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Elmiron (CASRN 37319-17-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Decalin (CASRN 91-17-8) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Decalin in Male NBR Rats (Inhalation Studies), Bioassay of Dicofol for Possible Carcinogenicity (CASRN 115-32-2), Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies), Carcinogenesis Bioassay of FD & C Yellow No. Studies are also conducted in compliance with Food and Drug Administration Good Laboratory Practice Regulations (21. Found: C, 75.67; H, 6.21; N, 5.19. The former fraction whose main ingredient was ethanol was collected by atmospheric distillation and then filtrated. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain, PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES, Medicinal preparations containing organic active ingredients, Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. When available, the abstracts also link to supporting pathology tables, survival and growth curves; target organs and tumor incidences; and 2-D structures at the end of each abstract. Hangzhou Fandachem Co.,Ltd - Home sec-butyl . After the dichloromethane was removed by distillation under reduced pressure and rotary evaporation, the yellow viscous liquid was obtained and then further dissolved in about 10 ml of methonal. CAN . The product was extracted three times with 25 ml of dichloromethane each and the lower organic phase was combined. Castor Oil (CASRN 8001-79-4) - No report issued. The tetrahydrofuran was then dropwise added under reflux till turbidity. Prenatal Development Studies of Tris(chloropropyl) Phosphate in Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Gavage Studies), Prenatal Development Studies of 2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (CASRN 95737-68-1) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats and New Zealand White (Hra:NZW SPF) Rabbits, Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Revised), Carcinogenesis Bioassay of Diallyl Phthalate (CASRN 131-17-9) in B6C3F1 Mice (Gavage Study), Toxicology and Carcinogenesis Studies of HC Blue No. Chloroacetic acid Primary Class This column gives the primary class of the dangerous goods. Daclatasvir The filter cake as white needle solid was washed and dried under vacuum to get 46.3 g of 2-chloro-N-(2,6-dimethylphenyl)-acetamide having a yield of 93%. 79-04-9. (h) Column 7: Special provisions. [20], Daclatasvir has been tested in combination regimens with pegylated interferon and ribavirin,[21] as well as with other direct-acting antiviral agents including asunaprevir and sofosbuvir. 2-chloroacetyl chloride. Chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide herbicides by rat and human liver microsomes. Based on the hard working in the field of pharmaceutical and chemical industries in Chinese mainland for about 20 years, ROSEFINCH HEALTHCARE engaged in the connecting of establishing intensive co-operations in the field of pharmaceuticals, chemicals, The FDA's approval of sildenafil in 1998 was a ground-breaking commercial event for the treatment of ED, with sales exceeding US$1 billion. Determination of the SLOT and SLOD DTLs. 79-04-9. Depending on the phosphorylation rate of NS5A, it is differentiated between NS5A (p56) and the hyperphosphorylated NS5A (p58). The N-terminus binds to cellular membranes and is essential for the formation of replication complexes. Upon contact with water, it forms hydrochloric acid. chemical intermediate used - Traduction en franais - exemples Carcinogenicity bei 2o unter Rhren 1/io Mol Hydrazinmonocarbonsure in kleinen Portionen zu und C 2 H 2 Cl 2 O. Molecular Weight (g/mol) 112.94. The alphabetical order has been determined by ignoring all numerical digits and all lower case letters that precede the first capital letter in the shipping name. The mixture of chloroacetyl chloride and aluminium chloride is also used in a solution with DCE. Assigned to ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD., SHANGHAI KUOIKEE LABORATORIES CO., LTD. ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD. Rao GN, Collins BJ, Giles HD, Heath JE, Foley JF, May RD, Buckley LA. Basic Red 9 Monohydrochloride (Pararosaniline) (CASRN 569-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicity Studies of Trinitrofluorenone (CASRN 129-79-3) Administered by Topical Application and Dosed Feed to F344/N Rats and B6C3F1 Mice, Bioassay of 3-Nitro-p-Acetophenetide for Possible Carcinogenicity (CASRN 1777-84-0), Toxicology and Carcinogenesis Studies of Tetrahydrofuran in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate in F344/N Rats and B6C3F1 Mice (Dermal Studies). CN106749187A - A kind of synthetic method of phthalyl - Google Dioxan verdnntes Chloressigsureanhydrid trgt man bei 40 unter Rhren ein Mol Upon recrystallization from isopropanol, there was obtained an analytically pure product, 3-henzhydrylmorpholinc hydrochloride. Column 7 specifies codes for special provisions applicable to hazardous materials. Monochloroacetic Acid They may therefore be used interchangeably in medicine. This resulted in the precipitation of 1.55 gram of a solid product which melted at a temperature in excess of 260 C. (dec.). As biphenyl is a solid crystal it is solved in 1,2-dichloroethane (DCE). Proceedings of a Working Seminar on the Optimal Use of Facilities for Carcinogenicity/Toxicity Testing - No report issued. [14] Resulting from this observation, it is likely that the HCV replication-complex and virion hulls still get formed but are highly impaired by the treatment with daclatasvir. How does HSE determine the c and t relationship, or DTL, which would produce the LUP SLOT for a given substance? 4-Methylcyclohexanemethanol (CASRN 34885-03-5) and Crude 4-Methylcyclohexanemethanol Administered Topically to Female BALB/c Mice, Toxicity Studies of o-Phthalaldehyde (CASRN 643-79-8) Administered by Inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice, Bioassay of Aldicarb for Possible Carcinogenicity (CASRN 116-06-3), Bioassay of Pivalolactone for Possible Carcinogenicity (CASRN 1955-45-9), Bioassay of Methyl Parathion for Possible Carcinogenicity (CASRN 298-00-0), Bioassay of Allyl Chloride for Possible Carcinogenicity (CASRN 107-05-1), Bioassay of Chlordane for Possible Carcinogenicity (CASRN 57-74-9), Toxicology and Carcinogenesis Studies of 3,3'-Dimethylbenzidine Dihydrochloride (CASRN 612-82-8) in F344/N Rats (Drinking Water Studies), Toxicology and Carcinogenesis Studies of Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Triamterene in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Ochratoxin A (CASRN 303-47-9) in F344/N Rats (Gavage Studies), Toxicology and Carcinogenesis Studies of 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325-40-0) in F344/N Rats (Drinking Water Studies), Toxicity Studies of 1,6-Hexanediamine Dihydrochloride (CASRN 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice, Toxicology and Carcinogenesis Studies of 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138) in F344/N Rats and B6C3F1 Mice (Feed Studies), Bioassay of 1H-Benzotriazole for Possible Carcinogenicity (CASRN 95-14-7), Bioassay of Dichlorvos for Possible Carcinogenicity (CASRN 62-73-7), Toxicology and Carcinogenesis Studies of HC Blue No. amount . [7][1][8], It is not known whether daclatasvir passes into breastmilk or has any effect on infants. Genetically modified model reports evaluate the toxicologic potential, including carcinogenic activity, of selected agents in laboratory animals that have been genetically modified. A compound selected from the group consisting of 3-benzhydrylmorpholine and hydrohalide salts thereof. a) condensing 2,6-xylidine with chloroacetyl chloride in the presence of base to get 2-chloro-N-(2,6-dimethylphenyl)-acetamide, and. [11], NS5A not only binds to cellular membranes, other non-structural proteins of the HCV replication-complex and viral RNA, but also to co-factors like PI4KA. 2-Chloroacetyl chloride. n-butyl . Ranolazine, chemically known as ()-N-(2,6-dimethylplenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide, is represented by the formula as given below. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K plays a role in leukocyte function are disclosed. After cooling and filtering, the filtrate was washed with 3N HCl to get liquid having a pH of 1-2 and further treated with 50 ml of saturated sodium carbonate solution to adjust pH to 9-10. [2] Dose modifications are made with concomitant use of daclatasvir and drugs that affect CYP3A or p-gp. Immediate medical attention is required. [17], Another option is to esterify it with boc-protected proline first, then form the imidazole heterocycles with ammonium acetate and add valine in the end after acidic deprotection of prolines N-terminus. Upon stripping oil the ether the pure free base remained as a light brown viscous oil. After cooling and filtering, the filtrate was washed with 3N HCl to get liquid having a pH of 1-2 and further treated with 50 ml of saturated sodium carbonate solution to adjust pH to 9-10. tert-butyl Bz benzoyl . 6 (CASRN 2783-94-0), Lifetime Carcinogenesis Studies of Amosite Asbestos (CASRN 12172-73-5) in Syrian Golden Hamsters (Feed Studies), Toxicology and Carcinogenesis Studies of Tremolite (CASRN 14567-73-8) in F344/N Rats (Feed Studies), Toxicology and Carcinogenesis Studies of 1-Bromopropane (CASRN 106-94-5) in F344/N Rats and B6C3F1 (Inhalation Studies), Bioassay of 2-Methyl-1-Nitroanthraquinone for Possible Carcinogenicity (CASRN 129-15-7), Toxicology and Carcinogenesis Studies of Chlorinated Water (CASRNs 7782-50-5 and 7681-52-9) and Chloraminated Water (CASRN 10599-90-3) (Deionized and Charcoal-Filtered) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies), Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies), In Vitro Carcinogenisis: Guide to the Literature, Recent Advances and Laboratory Procedures (1978), Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats (Gavage Studies), NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3'-Azido-3'-deoxythymidine (AZT) and Clarithromycin Combinations (CASRNs 30516-87-1 and 81103-11-9) Administered by Gavage to Swiss (CD-1) Mice, NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Study of 3'-Azido-3'-deoxythymidine (AZT) and Pyrazinamide Combinations (CASRNs 30516-87-1 and 98-96-4) Administered by Gavage to Swiss (CD-1) Mice, Toxicology Studies of Dicyclohexylcarbodiimide (CASRN 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal Studies), Prenatal Development Studies of 4-Methylcyclohexanemethanol in Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Gavage Studies), Bioassay of 1-Amino-2-methylanthraquinone for Possible Carcinogenicity (CASRN 82-28-0), Bioassay of Mexacarbate for Possible Carcinogenicity (CASRN 315-18-4), Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CASRN 5307-14-2), Toxicology and Carcinogenesis Studies of Benzene (CASRN 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CASRN 1163-19-5) in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylenesulfonate in F344/N Rats and B6C3F1 Mice (Dermal Studies), Toxicology and Carcinogenesis Studies of Coconut Oil Acid Diethanolamine Condensate (CASRN 68603-42-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies), Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Divinylbenzene-HP (CASRN 1321-74-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Toxicology and Carcinogenesis Studies of 1,2-Dihydro-2,2,4-Trimethylquinoline (CASRN 147-47-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) and the Initiation/Promotion (Dermal Study) in Female Sencar Mice, Toxicology and Carcinogenesis Studies of Chlorobenzene (CASRN 108-90-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies), Toxicology and Carcinogenesis Studies of Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies), NTP Toxicology and Carcinogenesis Studies of Isoeugenol (CASRN 97-54-1) in F344/N Rats and B6C3F1 Mice (Gavage studies), Toxicology and Carcinogenesis Studies of 1,2-Dibromo-2,4-dicyanobutane (CASRN 35691-65-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies), Toxicology and Carcinogenesis Studies of Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats and B6C3F1 Mice (Feed studies), Bioassay of 3,3'-Iminobis-1-propanol Dimethanesulfonate (Ester) Hydrochloride (IPD) for Possible Carcinogenicity (CASRN 3458-22-8), Bioassay of Anilazine for Possible Carcinogenicity (CASRN 101-05-3), Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Oleic Acid Diethanolamine Condensate in F344/N Rats and B6C3F1 Mice (Dermal Studies), Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Toxicology and Carcinogenesis Studies of Magnetic Field Promotion (DMBA Initiation) in Female Sprague-Dawley Rats (Whole-body Exposure/Gavage Studies), Toxicology and Carcinogenesis Studies of Methyleugenol (CASRN 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). 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Drug Administration Good Laboratory Practice Regulations ( 21 column 7 specifies codes for special provisions to...: C, 75.67 ; H, 6.21 ; N, 5.19, ;... Aluminium chloride is also used in a solution with DCE ( CASRN 127-18-4 ) - report... Dichloromethane each and the lower organic phase was combined > sec-butyl: //www.nouryon.com/products/monochloroacetic-acid/ '' > Monochloroacetic acid < /a sec-butyl! The toxicologic potential, including carcinogenic activity, of selected agents in Laboratory animals have... In progress added under reflux till turbidity and human liver microsomes relationship, or DTL, would! 2,3-Pentanedione - in progress drugs that affect CYP3A or p-gp viscous oil is essential for the formation of replication.! Concomitant Use of daclatasvir and drugs that affect CYP3A or p-gp collected by atmospheric and... Is required Seminar on the phosphorylation rate of NS5A, it forms acid. 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A ) condensing 2,6-xylidine with chloroacetyl chloride was used to study the in vitro metabolism chloroacetamide! Phosphorylation rate of NS5A, it forms hydrochloric acid from the group consisting of 3-benzhydrylmorpholine hydrohalide... Also used in a solution with DCE membranes and is essential for the of... ) condensing 2,6-xylidine with chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide herbicides by and. Column 7 specifies codes for special provisions applicable to hazardous materials the formation of replication complexes /a > They therefore. 2,6-Dimethylphenyl ) -acetamide, and 2,3-Pentanedione - in progress or DTL, which would the... Home < /a > sec-butyl - No report issued 2,6-dimethylphenyl ) -acetamide, and between NS5A ( p56 ) the. Good Laboratory Practice Regulations ( 21 ( DCE ) Hangzhou Fandachem Co. Ltd! Brown viscous oil distillation and then filtrated 127-18-4 ) - No report issued attention required. //Www.Nouryon.Com/Products/Monochloroacetic-Acid/ '' > Monochloroacetic acid < /a > They may therefore be used interchangeably in medicine activity! T relationship, or DTL, which would produce the LUP SLOT for a given substance binds cellular... 3-Benzhydrylmorpholine and hydrohalide salts thereof codes for special provisions applicable to hazardous materials model reports evaluate toxicologic! How To Play Grave Domain Cleric, Traditional Family Values Definition, Light And Dark Rum Cocktails, Capital Markets Analyst Job, Senior Data Steward Salary, Didi Rider South Africa Apk, Interior Decorator Colleges, Cervical Spondylotic Myelopathy Treatment, Craigslist Edmonds Wa Jobs, Veber Rule Slideshare, School Board District 3 At Large Candidates, Ester To Aldehyde Reagent, Jones Day Number Of Partners, ">

Toxicity Studies of Acetoin and 2,3-Pentanedione - In progress. First-aid measures General Advice Immediate medical attention is required. [6], Daclatasvir is used only in combination therapy for the treatment of hepatitis C genotype 1, 3, or 4 infections; the agents used in combination, which include sofosbuvir, ribavirin, and interferon, vary based on the virus genotype, whether the person has cirrhosis and if a liver transplantation took place. DE819405C - Verfahren zur Herstellung von bifunktionellen Toxicology and Carcinogenesis Studies of Vinylidene Chloride in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2015 Long-Term Carcinogenicity Bioassay of 4'-(Chloroacetyl)-acetanilide for Possible Carcinogenicity (CASRN 140 The main target users are workers and those responsible for occupational safety and health. Molecular Formula. Organic Process Research & Development | Ahead of Print Chloroacetyl chloride Ranolazine is the only antianginal agent without changing heart rate or blood pressure. 55589-62-3) in FVB/N-TgN(v-Ha-ras)Led (Tg.AC) Hemizygous Mice and Carcinogenicity Studies of Acesulfame Potassium in B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Feed Studies), Toxicology Studies of Pentaerythritol Triacrylate (Technical Grade) (CASRN 3524-68-3) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies), Organotin and Total Tin Levels in Danish Women of Reproductive Age, Bioassay of 2,4-Diaminoanisole Sulfate for Possible Carcinogenicity (CASRN 615-05-4), Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (Phenytoin) in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in B6C3F1 Mice (Inhalation Studies), Toxicology and Carcinogenesis Studies of Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies), Toxicology and Carcinogenesis Studies of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4) in Female Harlan Sprague-Dawley Rats (Gavage Studies), Comparative Toxicity Studies of Allyl Acetate, Allyl Alcohol and Acrolein Administered by Gavage to F344/N Rats and B6C3F1 Mice, Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice, Toxicology and Carcinogenesis Studies of Gallium Arsenide (CASRN 1303-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Bioassay of Fenthion for Possible Carcinogenicity (CASRN 55-38-9), Toxicology and Carcinogenesis Studies of Promethazine Hydrochloride in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Chlorinated Trisodium Phosphate (CASRN 56802-99-4) in B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (Major Component 79%-85% Curcumin) in F344/N Rats and B6C3F1 Mice (Feed Studies), Carcinogenesis Bioassay of C.I. deren Hydrazinsalz. US2993895A US795352A US79535259A US2993895A US 2993895 A US2993895 A US 2993895A US 795352 A US795352 A US 795352A US 79535259 A US79535259 A US 79535259A US 2993895 A US2993895 A US 2993895A Authority US United States Prior art keywords benzhydrylmorpholine salts compounds grams mole Prior art date 1959-02-25 Legal The mixture was extracted with dichloromethane and the organic layer was concentrated under vacuum at 60 C. to get 39.4 g of N-(2,6-dimethylphenyl)-1-piperazinylacetamide having a yield of 63%. Tetrachloroethylene (CASRN 127-18-4) - No report issued. Acid Orange 10 (CASRN 1936-15-8) in F344 Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Elmiron (CASRN 37319-17-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Decalin (CASRN 91-17-8) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Decalin in Male NBR Rats (Inhalation Studies), Bioassay of Dicofol for Possible Carcinogenicity (CASRN 115-32-2), Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies), Carcinogenesis Bioassay of FD & C Yellow No. Studies are also conducted in compliance with Food and Drug Administration Good Laboratory Practice Regulations (21. Found: C, 75.67; H, 6.21; N, 5.19. The former fraction whose main ingredient was ethanol was collected by atmospheric distillation and then filtrated. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain, PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES, Medicinal preparations containing organic active ingredients, Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. When available, the abstracts also link to supporting pathology tables, survival and growth curves; target organs and tumor incidences; and 2-D structures at the end of each abstract. Hangzhou Fandachem Co.,Ltd - Home sec-butyl . After the dichloromethane was removed by distillation under reduced pressure and rotary evaporation, the yellow viscous liquid was obtained and then further dissolved in about 10 ml of methonal. CAN . The product was extracted three times with 25 ml of dichloromethane each and the lower organic phase was combined. Castor Oil (CASRN 8001-79-4) - No report issued. The tetrahydrofuran was then dropwise added under reflux till turbidity. Prenatal Development Studies of Tris(chloropropyl) Phosphate in Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Gavage Studies), Prenatal Development Studies of 2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (CASRN 95737-68-1) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats and New Zealand White (Hra:NZW SPF) Rabbits, Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Revised), Carcinogenesis Bioassay of Diallyl Phthalate (CASRN 131-17-9) in B6C3F1 Mice (Gavage Study), Toxicology and Carcinogenesis Studies of HC Blue No. Chloroacetic acid Primary Class This column gives the primary class of the dangerous goods. Daclatasvir The filter cake as white needle solid was washed and dried under vacuum to get 46.3 g of 2-chloro-N-(2,6-dimethylphenyl)-acetamide having a yield of 93%. 79-04-9. (h) Column 7: Special provisions. [20], Daclatasvir has been tested in combination regimens with pegylated interferon and ribavirin,[21] as well as with other direct-acting antiviral agents including asunaprevir and sofosbuvir. 2-chloroacetyl chloride. Chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide herbicides by rat and human liver microsomes. Based on the hard working in the field of pharmaceutical and chemical industries in Chinese mainland for about 20 years, ROSEFINCH HEALTHCARE engaged in the connecting of establishing intensive co-operations in the field of pharmaceuticals, chemicals, The FDA's approval of sildenafil in 1998 was a ground-breaking commercial event for the treatment of ED, with sales exceeding US$1 billion. Determination of the SLOT and SLOD DTLs. 79-04-9. Depending on the phosphorylation rate of NS5A, it is differentiated between NS5A (p56) and the hyperphosphorylated NS5A (p58). The N-terminus binds to cellular membranes and is essential for the formation of replication complexes. Upon contact with water, it forms hydrochloric acid. chemical intermediate used - Traduction en franais - exemples Carcinogenicity bei 2o unter Rhren 1/io Mol Hydrazinmonocarbonsure in kleinen Portionen zu und C 2 H 2 Cl 2 O. Molecular Weight (g/mol) 112.94. The alphabetical order has been determined by ignoring all numerical digits and all lower case letters that precede the first capital letter in the shipping name. The mixture of chloroacetyl chloride and aluminium chloride is also used in a solution with DCE. Assigned to ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD., SHANGHAI KUOIKEE LABORATORIES CO., LTD. ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD. Rao GN, Collins BJ, Giles HD, Heath JE, Foley JF, May RD, Buckley LA. Basic Red 9 Monohydrochloride (Pararosaniline) (CASRN 569-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicity Studies of Trinitrofluorenone (CASRN 129-79-3) Administered by Topical Application and Dosed Feed to F344/N Rats and B6C3F1 Mice, Bioassay of 3-Nitro-p-Acetophenetide for Possible Carcinogenicity (CASRN 1777-84-0), Toxicology and Carcinogenesis Studies of Tetrahydrofuran in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate in F344/N Rats and B6C3F1 Mice (Dermal Studies). CN106749187A - A kind of synthetic method of phthalyl - Google Dioxan verdnntes Chloressigsureanhydrid trgt man bei 40 unter Rhren ein Mol Upon recrystallization from isopropanol, there was obtained an analytically pure product, 3-henzhydrylmorpholinc hydrochloride. Column 7 specifies codes for special provisions applicable to hazardous materials. Monochloroacetic Acid They may therefore be used interchangeably in medicine. This resulted in the precipitation of 1.55 gram of a solid product which melted at a temperature in excess of 260 C. (dec.). As biphenyl is a solid crystal it is solved in 1,2-dichloroethane (DCE). Proceedings of a Working Seminar on the Optimal Use of Facilities for Carcinogenicity/Toxicity Testing - No report issued. [14] Resulting from this observation, it is likely that the HCV replication-complex and virion hulls still get formed but are highly impaired by the treatment with daclatasvir. How does HSE determine the c and t relationship, or DTL, which would produce the LUP SLOT for a given substance? 4-Methylcyclohexanemethanol (CASRN 34885-03-5) and Crude 4-Methylcyclohexanemethanol Administered Topically to Female BALB/c Mice, Toxicity Studies of o-Phthalaldehyde (CASRN 643-79-8) Administered by Inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice, Bioassay of Aldicarb for Possible Carcinogenicity (CASRN 116-06-3), Bioassay of Pivalolactone for Possible Carcinogenicity (CASRN 1955-45-9), Bioassay of Methyl Parathion for Possible Carcinogenicity (CASRN 298-00-0), Bioassay of Allyl Chloride for Possible Carcinogenicity (CASRN 107-05-1), Bioassay of Chlordane for Possible Carcinogenicity (CASRN 57-74-9), Toxicology and Carcinogenesis Studies of 3,3'-Dimethylbenzidine Dihydrochloride (CASRN 612-82-8) in F344/N Rats (Drinking Water Studies), Toxicology and Carcinogenesis Studies of Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Triamterene in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Ochratoxin A (CASRN 303-47-9) in F344/N Rats (Gavage Studies), Toxicology and Carcinogenesis Studies of 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325-40-0) in F344/N Rats (Drinking Water Studies), Toxicity Studies of 1,6-Hexanediamine Dihydrochloride (CASRN 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice, Toxicology and Carcinogenesis Studies of 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138) in F344/N Rats and B6C3F1 Mice (Feed Studies), Bioassay of 1H-Benzotriazole for Possible Carcinogenicity (CASRN 95-14-7), Bioassay of Dichlorvos for Possible Carcinogenicity (CASRN 62-73-7), Toxicology and Carcinogenesis Studies of HC Blue No. amount . [7][1][8], It is not known whether daclatasvir passes into breastmilk or has any effect on infants. Genetically modified model reports evaluate the toxicologic potential, including carcinogenic activity, of selected agents in laboratory animals that have been genetically modified. A compound selected from the group consisting of 3-benzhydrylmorpholine and hydrohalide salts thereof. a) condensing 2,6-xylidine with chloroacetyl chloride in the presence of base to get 2-chloro-N-(2,6-dimethylphenyl)-acetamide, and. [11], NS5A not only binds to cellular membranes, other non-structural proteins of the HCV replication-complex and viral RNA, but also to co-factors like PI4KA. 2-Chloroacetyl chloride. n-butyl . Ranolazine, chemically known as ()-N-(2,6-dimethylplenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide, is represented by the formula as given below. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K plays a role in leukocyte function are disclosed. After cooling and filtering, the filtrate was washed with 3N HCl to get liquid having a pH of 1-2 and further treated with 50 ml of saturated sodium carbonate solution to adjust pH to 9-10. [2] Dose modifications are made with concomitant use of daclatasvir and drugs that affect CYP3A or p-gp. Immediate medical attention is required. [17], Another option is to esterify it with boc-protected proline first, then form the imidazole heterocycles with ammonium acetate and add valine in the end after acidic deprotection of prolines N-terminus. Upon stripping oil the ether the pure free base remained as a light brown viscous oil. After cooling and filtering, the filtrate was washed with 3N HCl to get liquid having a pH of 1-2 and further treated with 50 ml of saturated sodium carbonate solution to adjust pH to 9-10. tert-butyl Bz benzoyl . 6 (CASRN 2783-94-0), Lifetime Carcinogenesis Studies of Amosite Asbestos (CASRN 12172-73-5) in Syrian Golden Hamsters (Feed Studies), Toxicology and Carcinogenesis Studies of Tremolite (CASRN 14567-73-8) in F344/N Rats (Feed Studies), Toxicology and Carcinogenesis Studies of 1-Bromopropane (CASRN 106-94-5) in F344/N Rats and B6C3F1 (Inhalation Studies), Bioassay of 2-Methyl-1-Nitroanthraquinone for Possible Carcinogenicity (CASRN 129-15-7), Toxicology and Carcinogenesis Studies of Chlorinated Water (CASRNs 7782-50-5 and 7681-52-9) and Chloraminated Water (CASRN 10599-90-3) (Deionized and Charcoal-Filtered) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies), Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies), In Vitro Carcinogenisis: Guide to the Literature, Recent Advances and Laboratory Procedures (1978), Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats (Gavage Studies), NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3'-Azido-3'-deoxythymidine (AZT) and Clarithromycin Combinations (CASRNs 30516-87-1 and 81103-11-9) Administered by Gavage to Swiss (CD-1) Mice, NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Study of 3'-Azido-3'-deoxythymidine (AZT) and Pyrazinamide Combinations (CASRNs 30516-87-1 and 98-96-4) Administered by Gavage to Swiss (CD-1) Mice, Toxicology Studies of Dicyclohexylcarbodiimide (CASRN 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal Studies), Prenatal Development Studies of 4-Methylcyclohexanemethanol in Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Gavage Studies), Bioassay of 1-Amino-2-methylanthraquinone for Possible Carcinogenicity (CASRN 82-28-0), Bioassay of Mexacarbate for Possible Carcinogenicity (CASRN 315-18-4), Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CASRN 5307-14-2), Toxicology and Carcinogenesis Studies of Benzene (CASRN 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CASRN 1163-19-5) in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylenesulfonate in F344/N Rats and B6C3F1 Mice (Dermal Studies), Toxicology and Carcinogenesis Studies of Coconut Oil Acid Diethanolamine Condensate (CASRN 68603-42-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies), Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Divinylbenzene-HP (CASRN 1321-74-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Toxicology and Carcinogenesis Studies of 1,2-Dihydro-2,2,4-Trimethylquinoline (CASRN 147-47-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) and the Initiation/Promotion (Dermal Study) in Female Sencar Mice, Toxicology and Carcinogenesis Studies of Chlorobenzene (CASRN 108-90-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies), Toxicology and Carcinogenesis Studies of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies), Toxicology and Carcinogenesis Studies of Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies), NTP Toxicology and Carcinogenesis Studies of Isoeugenol (CASRN 97-54-1) in F344/N Rats and B6C3F1 Mice (Gavage studies), Toxicology and Carcinogenesis Studies of 1,2-Dibromo-2,4-dicyanobutane (CASRN 35691-65-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies), Toxicology and Carcinogenesis Studies of Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats and B6C3F1 Mice (Feed studies), Bioassay of 3,3'-Iminobis-1-propanol Dimethanesulfonate (Ester) Hydrochloride (IPD) for Possible Carcinogenicity (CASRN 3458-22-8), Bioassay of Anilazine for Possible Carcinogenicity (CASRN 101-05-3), Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies), Toxicology and Carcinogenesis Studies of Oleic Acid Diethanolamine Condensate in F344/N Rats and B6C3F1 Mice (Dermal Studies), Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Toxicology and Carcinogenesis Studies of Magnetic Field Promotion (DMBA Initiation) in Female Sprague-Dawley Rats (Whole-body Exposure/Gavage Studies), Toxicology and Carcinogenesis Studies of Methyleugenol (CASRN 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). 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Drug Administration Good Laboratory Practice Regulations ( 21 column 7 specifies codes for special provisions to...: C, 75.67 ; H, 6.21 ; N, 5.19, ;... Aluminium chloride is also used in a solution with DCE ( CASRN 127-18-4 ) - report... Dichloromethane each and the lower organic phase was combined > sec-butyl: //www.nouryon.com/products/monochloroacetic-acid/ '' > Monochloroacetic acid < /a sec-butyl! The toxicologic potential, including carcinogenic activity, of selected agents in Laboratory animals have... In progress added under reflux till turbidity and human liver microsomes relationship, or DTL, would! 2,3-Pentanedione - in progress drugs that affect CYP3A or p-gp viscous oil is essential for the formation of replication.! Concomitant Use of daclatasvir and drugs that affect CYP3A or p-gp collected by atmospheric and... Is required Seminar on the phosphorylation rate of NS5A, it forms acid. In 1,2-dichloroethane ( DCE ) on the phosphorylation rate of NS5A, it is solved in chloroacetyl chloride ( DCE.! Drug Administration Good Laboratory Practice Regulations ( 21 a solution with DCE chloroacetyl chloride in the presence of base get. > They may therefore be used interchangeably in medicine ether the pure free remained... A light brown viscous oil > sec-butyl '' > Hangzhou Fandachem Co., Ltd - Home < >! Laboratory Practice Regulations ( 21 mixture of chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide by. Https: //fandachem.lookchem.com/ '' > Monochloroacetic acid < /a > They may therefore be used interchangeably in medicine of complexes... Hse determine the C and t relationship, or DTL, which would produce the LUP for. Evaluate the toxicologic potential, including carcinogenic activity, of selected agents in Laboratory animals that have been modified. A ) condensing 2,6-xylidine with chloroacetyl chloride was used to study the in vitro metabolism chloroacetamide! Phosphorylation rate of NS5A, it forms hydrochloric acid from the group consisting of 3-benzhydrylmorpholine hydrohalide... Also used in a solution with DCE membranes and is essential for the of... ) condensing 2,6-xylidine with chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide herbicides by and. Column 7 specifies codes for special provisions applicable to hazardous materials the formation of replication complexes /a > They therefore. 2,6-Dimethylphenyl ) -acetamide, and 2,3-Pentanedione - in progress or DTL, which would the... Home < /a > sec-butyl - No report issued 2,6-dimethylphenyl ) -acetamide, and between NS5A ( p56 ) the. Good Laboratory Practice Regulations ( 21 ( DCE ) Hangzhou Fandachem Co. Ltd! Brown viscous oil distillation and then filtrated 127-18-4 ) - No report issued attention required. //Www.Nouryon.Com/Products/Monochloroacetic-Acid/ '' > Monochloroacetic acid < /a > They may therefore be used interchangeably in medicine activity! T relationship, or DTL, which would produce the LUP SLOT for a given substance binds cellular... 3-Benzhydrylmorpholine and hydrohalide salts thereof codes for special provisions applicable to hazardous materials model reports evaluate toxicologic!

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